Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8079535 | 0.78 | — | — | |
| Tromethamine SCHEMBL5694600 | 0.76 | MEN1 (0.40) | MEN1LMNAKMT2A | |
| Hydrochloric Acid SCHEMBL29080676 | 0.75 | — | — | |
| Tromethamine SCHEMBL7994563 | 0.73 | MEN1 (0.37) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL19716179 | 0.69 | S1PR1 (0.44) | — | |
| Nitric Acid SCHEMBL10708763 | 0.67 | CA5A (0.35) | — | |
| Tromethamine SCHEMBL1526047 | 0.64 | — | — | |
| Tromethamine SCHEMBL1285696 | 0.64 | MEN1 (0.83) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL20658226 | 0.64 | MEN1 (0.83) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL7193959 | 0.64 | MEN1 (0.83) | MEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048523-B2 | Cerium oxide nanoparticles | NANOGRAM CORPORATION (US) | 2011-11-01 | — | — | US | claimed |
| US-20090233098-A1 | CERIUM OXIDE NANOPARTICLES | NANOGRAM CORPORATION | 2009-09-17 | — | — | US | claimed |
| US-8048523-B2 | Cerium oxide nanoparticles | NANOGRAM CORPORATION (US) | 2011-11-01 | — | — | US | disclosed |
| US-20090233098-A1 | CERIUM OXIDE NANOPARTICLES | NANOGRAM CORPORATION | 2009-09-17 | — | — | US | disclosed |
| EP-1027721-B1 | ARTICLES OR COMPOSITIONS COMPRISING NANOSCALE PARTICLES; METHODS OF UTILIZING OR PRODUCING SUCH PARTICLES | NANOGRAM CORP (US) | 2008-06-25 | — | — | EP | disclosed |
| US-20080003522-A1 | Photoresist with metal oxide nanoparticles | NANOGRAM CORPORATION | 2008-01-03 | — | — | US | disclosed |
| US-20050232878-A1 | Ultraviolet light block and photocatalytic materials | NANOGRAM CORPORATION | 2005-10-20 | — | — | US | disclosed |
| US-6099798-A | USED TO SHIELD INDIVIDUALS FROM HARMFUL ULTRAVIOLET RADIATION; THESE PARTICLES CAN ALSO BE USED IN INDUSTRIAL PROCESSING TO PRODUCE SOLID STATE ELECTRONIC DEVICES BY CREATING EDGES OF PHOTORESIST MATERIAL WITH A HIGH ASPECT RATIO | NANOGRAM CORP. (US) | 2000-08-08 | — | — | US | disclosed |