SCHEMBL7995072

SCHEMBL7995072

COC(=O)c1ccc(Oc2cccnc2)c(C(F)(F)F)c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.53
KMT2A Q03164 2/20 0.53
KDM4E B2RXH2 1/20 0.53
MEN1 O00255 1/20 0.53
GAA P10253 1/20 0.53
MAPK1 P28482 1/20 0.53
CYP19A1 P11511 1/20 0.50
CYP11B1 P15538 1/20 0.50
CYP11B2 P19099 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.48
CFTR P13569 1/20 0.47
NOTUM Q6P988 1/20 0.47
ALPL P05186 1/20 0.47
CYP1A2 P05177 2/20 0.45
HTR2A P28223 2/20 0.45
HTR2C P28335 2/20 0.45
HTR2B P41595 1/20 0.45
NPC1 O15118 1/20 0.45
TNF P01375 1/20 0.45
RAB9A P51151 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8179909 0.91 ALDH1A1 (0.51) ALDH1A1KMT2AKDM4EMEN1GAA
SCHEMBL8075068 0.85 NOTUM (0.54) ALDH1A1KDM4EGAANOTUMRAB9A
SCHEMBL27436629 0.83 SMN1; SMN2 (0.51) ALDH1A1KMT2AKDM4EMEN1GAA
SCHEMBL8184159 0.83 ALDH1A1 (0.50) ALDH1A1KMT2AKDM4EMEN1GAA
SCHEMBL8471350 0.81 USP2 (0.65) ALDH1A1KMT2AKDM4EMEN1GAA
SCHEMBL8831863 0.81 SMN1; SMN2 (0.49) ALDH1A1KMT2AKDM4EMEN1GAA
SCHEMBL5167385 0.81 CFTR (0.67) ALDH1A1KMT2AKDM4EMEN1GAA
SCHEMBL8185434 0.81 SLC9A1 (0.52) ALDH1A1KMT2AKDM4EMEN1GAA
Hydrochloric Acid SCHEMBL8379790 0.80 SMN1; SMN2 (0.48) ALDH1A1KMT2AKDM4EMEN1GAA
SCHEMBL8179683 0.79 ALDH1A1 (0.61) ALDH1A1KMT2AKDM4EMEN1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6022883-A Heterocyclyloxybenzoylguanidines MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 2000-02-08 US disclosed
US-6022899-A EFFECTIVE INHIBITORS OF THE CELLULAR SODIUM PROTON ANTIPORTER HOECHST AKTIENGESELLSCHAFT (DE) 2000-02-08 US disclosed
US-5753710-A INHIBITORS OF THE CELLULAR SODIUM PROTON ANTIPORTER HOECHST AKTIENGESELLSCHAFT (DE) 1998-05-19 US disclosed
US-5665739-A CARDIOVASCULAR DISORDERS HOECHST AKTIENGESELLSCHAFT (DE) 1997-09-09 US disclosed
US-5641792-A CARDIOTONIC AGENTS, ALSO FOR STROKES AND NERVOUS SYSTEM DISORDERS HOECHST AKTIENGESELLSCHAFT (DE) 1997-06-24 US disclosed
CN-1126202-A Heterocyclyloxy benzoylguanidin MERCK PATENT GMBH (DE) 1996-07-10 CN disclosed