Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 3/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD5 | P21918 | 1/20 | 0.35 |
| ▸ | CCKBR | P32239 | 4/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.33 |
| ▸ | STAT6 | P42226 | 1/20 | 0.33 |
| ▸ | PYGL | P06737 | 3/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.32 |
| ▸ | PYGM | P11217 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8008787 | 1.00 | DRD2 (0.35) | DRD2HTR2CDRD3DRD1DRD4 | |
| SCHEMBL8010535 | 0.92 | DRD2 (0.37) | DRD2CCKBRCYP51A1STAT6PYGL | |
| SCHEMBL8004905 | 0.85 | DRD2 (0.38) | DRD2HTR2CCCKBRCYP51A1STAT6 | |
| SCHEMBL4055536 | 0.82 | DRD2 (0.35) | DRD2HTR2CDRD3DRD1DRD4 | |
| SCHEMBL8007233 | 0.82 | DRD2 (0.37) | DRD2HTR2CDRD3DRD1DRD4 | |
| SCHEMBL8008199 | 0.80 | DRD2 (0.44) | DRD2HTR2CDRD3CCKBRCYP51A1 | |
| SCHEMBL7995203 | 0.79 | DRD2 (0.37) | DRD2HTR2CDRD3DRD1DRD4 | |
| SCHEMBL8004902 | 0.76 | DRD2 (0.38) | DRD2HTR2CCCKBRCYP51A1STAT6 | |
| SCHEMBL4050168 | 0.75 | DRD2 (0.36) | DRD2HTR2CDRD3DRD1DRD4 | |
| SCHEMBL4058360 | 0.74 | DRD2 (0.36) | DRD2HTR2CDRD3DRD1DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009111680-A1 | TRPV4 ANTAGONISTS | SMITHLINE BEECHAM CORPORATION (US) | 2009-09-11 | — | — | WO | disclosed |