Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | CCKBR | P32239 | 5/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | STAT6 | P42226 | 1/20 | 0.39 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | PYGL | P06737 | 2/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8004902 | 0.86 | DRD2 (0.38) | DRD2CCKBRHTR2CSTAT6CYP51A1 | |
| SCHEMBL7995203 | 0.85 | DRD2 (0.37) | DRD2CCKBRHTR2CSTAT6CYP51A1 | |
| SCHEMBL8007233 | 0.85 | DRD2 (0.37) | DRD2CCKBRHTR2CSTAT6CYP51A1 | |
| SCHEMBL8004905 | 0.83 | DRD2 (0.38) | DRD2CCKBRHTR2CSTAT6CYP51A1 | |
| SCHEMBL8010535 | 0.82 | DRD2 (0.37) | DRD2CCKBRSTAT6CYP51A1PYGL | |
| SCHEMBL8008787 | 0.80 | DRD2 (0.35) | DRD2CCKBRHTR2CSTAT6CYP51A1 | |
| SCHEMBL7995186 | 0.80 | DRD2 (0.35) | DRD2CCKBRHTR2CSTAT6CYP51A1 | |
| SCHEMBL7944428 | 0.80 | DRD2 (0.51) | DRD2CCKBRSTAT6CYP51A1DRD3 | |
| SCHEMBL8008794 | 0.79 | STAT6 (0.40) | DRD2CCKBRSTAT6CYP51A1DRD3 | |
| SCHEMBL7995570 | 0.75 | DRD2 (0.38) | DRD2CCKBRSTAT6CYP51A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009111680-A1 | TRPV4 ANTAGONISTS | SMITHLINE BEECHAM CORPORATION (US) | 2009-09-11 | — | — | WO | disclosed |