Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 7/20 | 0.46 |
| ▸ | FEN1 | P39748 | 7/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7995594 | 0.83 | F10 (0.42) | ALOX5APFEN1F2PRSS1 | |
| SCHEMBL7995533 | 0.79 | ALOX5AP (0.49) | ALOX5APFEN1 | |
| SCHEMBL7995555 | 0.78 | ALOX5AP (0.44) | ALOX5APFEN1KMT2ASMN1; SMN2F2 | |
| SCHEMBL7994282 | 0.77 | F2 (0.41) | ALOX5APFEN1KMT2AF2PRSS1 | |
| SCHEMBL15915964 | 0.74 | ALOX5AP (0.61) | ALOX5APFEN1KMT2AMEN1KDM4E | |
| SCHEMBL9307372 | 0.72 | ALOX5AP (0.52) | ALOX5APFEN1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL7994136 | 0.67 | ALOX5AP (0.54) | ALOX5APFEN1 | |
| SCHEMBL21049716 | 0.67 | ALOX5AP (0.60) | ALOX5APFEN1SMN1; SMN2KDM4ECASP1 | |
| SCHEMBL7995485 | 0.66 | FEN1 (0.41) | ALOX5APFEN1 | |
| SCHEMBL7995476 | 0.66 | F10 (0.44) | ALOX5APFEN1PRSS1POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0810858-A4 | BORONIC ACID AND ESTER INHIBITORS OF THROMBIN | DU PONT PHARM CO (US) | 2000-11-15 | — | — | EP | disclosed |
| EP-0810858-A2 | BORONIC ACID AND ESTER INHIBITORS OF THROMBIN | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1997-12-10 | — | — | EP | disclosed |
| WO-1996020689-A2 | BORONIC ACID AND ESTER INHIBITORS OF THROMBIN | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-07-11 | — | — | WO | disclosed |