Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.35 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7995485 | 0.88 | FEN1 (0.41) | ALOX5APFEN1 | |
| SCHEMBL7995533 | 0.85 | ALOX5AP (0.49) | ALOX5APFEN1 | |
| SCHEMBL7995594 | 0.82 | F10 (0.42) | F2PRSS1MCL1ALOX5APFEN1 | |
| SCHEMBL7994283 | 0.78 | F2 (0.38) | F2PRSS1MCL1AGTR1AGTR2 | |
| SCHEMBL7995553 | 0.77 | ALOX5AP (0.46) | F2PRSS1ALOX5APFEN1KDM4E | |
| SCHEMBL10916572 | 0.76 | CASP1 (0.51) | AGTR1AGTR2 | |
| SCHEMBL7994136 | 0.73 | ALOX5AP (0.54) | ALOX5APFEN1 | |
| SCHEMBL7128878 | 0.71 | ALOX5AP (0.53) | ALOX5APFEN1 | |
| SCHEMBL7994011 | 0.70 | ALOX5AP (0.42) | ALOX5APFEN1 | |
| SCHEMBL7130070 | 0.70 | ALOX5AP (0.55) | ALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0810858-A4 | BORONIC ACID AND ESTER INHIBITORS OF THROMBIN | DU PONT PHARM CO (US) | 2000-11-15 | — | — | EP | disclosed |
| EP-0810858-A2 | BORONIC ACID AND ESTER INHIBITORS OF THROMBIN | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1997-12-10 | — | — | EP | disclosed |
| WO-1996020689-A2 | BORONIC ACID AND ESTER INHIBITORS OF THROMBIN | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-07-11 | — | — | WO | disclosed |