Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 5/20 | 0.54 |
| ▸ | CTSS | P25774 | 4/20 | 0.54 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 3/20 | 0.45 |
| ▸ | PPARA | Q07869 | 3/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | PPARD | Q03181 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7943806 | 0.83 | CTSS (0.49) | CTSKCTSSCTSLCTSBMMP13 | |
| SCHEMBL6609045 | 0.80 | CTSK (0.55) | CTSKCTSSCTSLCTSBGABRB1 | |
| SCHEMBL1193789 | 0.80 | CTSK (0.55) | CTSKCTSSCTSLCTSBGABRB1 | |
| SCHEMBL1194009 | 0.80 | CTSK (0.55) | CTSKCTSSCTSLCTSBGABRB1 | |
| SCHEMBL8910232 | 0.79 | CTSS (0.46) | CTSKCTSSCTSLCTSBMMP13 | |
| SCHEMBL9404277 | 0.79 | CTSS (0.46) | CTSKCTSSCTSLCTSBMMP13 | |
| SCHEMBL7747398 | 0.79 | CTSS (0.46) | CTSKCTSSCTSLCTSBMMP13 | |
| SCHEMBL14820895 | 0.79 | CTSK (0.57) | CTSKCTSSCTSLCTSBGABRB1 | |
| SCHEMBL7747410 | 0.78 | PPARA (0.45) | CTSKCTSSCTSLCTSBMMP13 | |
| SCHEMBL7748907 | 0.78 | PPARA (0.45) | CTSKCTSSCTSLCTSBMMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6114550-A | Method for the stereo-selective preparation of a derivative of β-phenyl-isoserine and its use in the preparation of taxane derivatives | RHONE-POULENC RORER S.A. (FR) | 2000-09-05 | — | — | US | disclosed |
| US-5726346-A | Process for the stereoselective preparation of a β-phenylisoserine derivative and its use for the preparation of taxane derivatives | RHONE-POULENC RORER S.A. (FR) | 1998-03-10 | — | — | US | disclosed |
| EP-0663901-B1 | METHOD FOR THE STEREOSELECTIVE PREPARATION OF A DERIVATIVE OF BETA-PHENYLISOSERINE AND ITS USE IN THE PREPARATION OF TAXANE DERIVATIVES | RHONE POULENC RORER SA (FR) | 1997-03-19 | — | — | EP | disclosed |
| EP-0663901-A1 | METHOD FOR THE STEREOSELECTIVE PREPARATION OF A DERIVATIVE OF -g(b)-PHENYLISOSERINE AND ITS USE IN THE PREPARATION OF TAXANE DERIVATIVES. | RHONE POULENC RORER SA (FR) | 1995-07-26 | — | — | EP | disclosed |
| WO-1994007847-A1 | METHOD FOR THE STEREOSELECTIVE PREPARATION OF A DERIVATIVE OF β-PHENYLISOSERINE AND ITS USE IN THE PREPARATION OF TAXANE DERIVATIVES | RHONE-POULENC RORER S.A. (FR) | 1994-04-14 | — | — | WO | disclosed |