Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 6/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 6/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 5/20 | 0.37 |
| ▸ | GRIN2C | Q14957 | 5/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propionic Acid SCHEMBL11785368 | 0.89 | OPRM1 (0.46) | KCNA5ALDH1A1MEN1KMT2ACYP2D6 | |
| SCHEMBL9723670 | 0.78 | CYP2D6 (0.48) | ALDH1A1KDM4EMEN1KMT2ACRHBP | |
| SCHEMBL10539701 | 0.75 | KCNA5 (0.51) | KCNA5ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL18911440 | 0.70 | LMNA (0.44) | ALDH1A1MEN1KMT2ACYP2C19MAPT | |
| SCHEMBL14663983 | 0.70 | KCNA5 (0.46) | KCNA5ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL9320598 | 0.70 | KCNA5 (0.46) | KCNA5ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL8907881 | 0.70 | KCNA5 (0.46) | KCNA5ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL616297 | 0.68 | MAPT (0.49) | KCNA5KDM4EKMT2ACYP2D6MAPT | |
| SCHEMBL6579332 | 0.68 | KCNA5 (0.45) | KCNA5ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL6579342 | 0.68 | KCNA5 (0.45) | KCNA5ALDH1A1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0873298-A4 | CHIRAL REDUCTIONS OF IMINES LEADING TO THE SYNTHESES OF OPTICALLY ACTIVE AMINES | NPS PHARMA INC (US) | 2000-05-17 | — | — | EP | disclosed |
| EP-0873298-A1 | CHIRAL REDUCTIONS OF IMINES LEADING TO THE SYNTHESES OF OPTICALLY ACTIVE AMINES | NPS PHARMACEUTICALS, INC. (US) | 1998-10-28 | — | — | EP | disclosed |
| US-5648541-A | FORMING ENANTIOMERS FROM IMINES BY REDUCTION WITH LITHIUM ALUMINUM HYDRIDE | NPS PHARMACEUTICALS, INC. (US) | 1997-07-15 | — | — | US | disclosed |
| WO-1997011934-A1 | CHIRAL REDUCTIONS OF IMINES LEADING TO THE SYNTHESES OF OPTICALLY ACTIVE AMINES | NPS PHARMACEUTICALS, INC. (US) | 1997-04-03 | — | — | WO | disclosed |
| US-5284975-A | Method of preparing α-d-phenylalkylbenzyl carbinol | MALLINCKRODT SPECIALTY CHEMICALS COMPANY (US) | 1994-02-08 | — | — | US | disclosed |
| US-5132457-A | Stereospecific synthesis of 2(R)-2-methyl-3-dimethylamino-propiophenone (d-DAMP) | MALLINCKRODT SPECIALTY CHEMICALS COMPANY (US) | 1992-07-21 | — | — | US | disclosed |
| EP-0044984-A1 | Process for the optical resolution of mixtures of d- and l-2-(6-methoxy-2-naphthyl)-propionic acids, the cinchonidine salt of d-2-(6-methoxy-2-naphthyl)-propionic acid and the preparation thereof | ALFA FARMACEUTICI S.p.A. (IT) | 1982-02-03 | — | — | EP | disclosed |