Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK1 | P04183 | 4/20 | 0.39 |
| ▸ | TK2 | O00142 | 10/20 | 0.38 |
| ▸ | TYMP | P19971 | 1/20 | 0.36 |
| ▸ | RNASE1 | P07998 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6830770 | 0.85 | TK2 (0.43) | TK1TK2TYMPRNASE1 | |
| SCHEMBL6827415 | 0.84 | TK2 (0.45) | TK1TK2RNASE1 | |
| SCHEMBL6323179 | 0.83 | TK2 (0.42) | TK1TK2TYMPRNASE1 | |
| SCHEMBL6831419 | 0.83 | TK1 (0.38) | TK1TK2TYMP | |
| SCHEMBL6831414 | 0.83 | TK1 (0.38) | TK1TK2TYMP | |
| SCHEMBL6832155 | 0.83 | TK2 (0.42) | TK1TK2TYMPRNASE1 | |
| SCHEMBL6830104 | 0.82 | TK1 (0.34) | TK1TK2TYMPRNASE1 | |
| SCHEMBL6831283 | 0.82 | TK2 (0.41) | TK1TK2TYMPRNASE1 | |
| SCHEMBL6830086 | 0.82 | TK1 (0.34) | TK1TK2TYMPRNASE1 | |
| SCHEMBL8987793 | 0.81 | TK2 (0.41) | TK1TK2TYMPRNASE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6121437-A | SYNTHESIS OF OLIGONUCLEOTIDES USING OLIGONUCLEOTIDES OR NUCLEOTIDES WITH PROTECTED INTERNUCLEOSIDIC PHOSPHORUS FUNCTIONALITIES WHICH CAN BE REMOVED UNDER MILD CONDITIONS AND PRODUCE NONTOXIC BY-PRODUCTS | ISIS PHARMACEUTICALS, INC. (US) | 2000-09-19 | — | — | US | disclosed |