Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK1 | P04183 | 5/20 | 0.34 |
| ▸ | TK2 | O00142 | 8/20 | 0.34 |
| ▸ | RNASE1 | P07998 | 1/20 | 0.33 |
| ▸ | TYMP | P19971 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6830086 | 0.92 | TK1 (0.34) | TK1TK2RNASE1TYMP | |
| SCHEMBL6827472 | 0.87 | TK1 (0.32) | TK1TK2RNASE1 | |
| SCHEMBL3290516 | 0.84 | RNASE1 (0.43) | TK1TK2RNASE1TYMP | |
| SCHEMBL6830095 | 0.83 | TK2 (0.35) | TK1TK2RNASE1 | |
| SCHEMBL7995787 | 0.82 | TK1 (0.39) | TK1TK2RNASE1TYMP | |
| SCHEMBL6831283 | 0.81 | TK2 (0.41) | TK1TK2RNASE1TYMP | |
| SCHEMBL6830791 | 0.79 | NT5M (0.33) | TK1TK2RNASE1 | |
| SCHEMBL6830770 | 0.79 | TK2 (0.43) | TK1TK2RNASE1TYMP | |
| SCHEMBL2113959 | 0.78 | TYMP (0.37) | TK1TK2TYMP | |
| SCHEMBL6830784 | 0.77 | RNASE1 (0.39) | TK1TK2RNASE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6743902-B1 | FOR USE IN ANTISENSE THERAPY FOR ENHANCING NUCLEASE RESISTANCE AND CELLULAR UPTAKE | VALEANT PHARMACEUTICALS INTERNATIONAL | 2004-06-01 | — | — | US | disclosed |
| US-5712378-A | SUGAR MOLECULE IS SUBSTITUTED WITH HYDROCARBON OR SUBSTITUTED HYDROCARBON GROUPS, ANTISENSE AGENTS | ICN PHARMACEUTICALS (US) | 1998-01-27 | — | — | US | disclosed |