Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTTP | P55157 | 15/20 | 0.53 |
| ▸ | APOB | P04114 | 6/20 | 0.49 |
| ▸ | SMO | Q99835 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6795426 | 0.84 | SMO (0.56) | MTTPAPOBSMO | |
| SCHEMBL6793489 | 0.82 | SMO (0.62) | MTTPAPOBSMO | |
| SCHEMBL14465601 | 0.82 | APOB (0.44) | MTTPAPOBSMO | |
| SCHEMBL6648279 | 0.80 | MTTP (0.60) | MTTPAPOB | |
| SCHEMBL6805247 | 0.77 | MTTP (0.49) | MTTPAPOBSMOGAA | |
| SCHEMBL6793203 | 0.77 | TRPV1 (0.53) | MTTPAPOBSMOGAA | |
| SCHEMBL6495258 | 0.76 | SMO (0.48) | MTTPAPOBSMO | |
| SCHEMBL31393757 | 0.76 | CHRNB2 (0.71) | MTTPAPOBGAA | |
| SCHEMBL6794354 | 0.75 | SMO (0.61) | MTTPAPOBSMO | |
| SCHEMBL6805714 | 0.75 | MTTP (0.66) | MTTP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001077077-A1 | SUBSTITUTED (HETERO)ARYL CARBOXAMIDE DERIVATIVES AS MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) AND APOLIPOPROTEIN B (APO B) SECRETION | NOVARTIS AG (CH) | 2001-10-18 | — | — | WO | disclosed |