Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7999911 | 0.85 | ALDH1A1 (0.49) | POLBRAB9ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL7995971 | 0.82 | ALDH1A1 (0.54) | POLBRAB9ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL7995969 | 0.82 | ALDH1A1 (0.54) | POLBRAB9ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL12309435 | 0.79 | ALDH1A1 (0.68) | POLBRAB9ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL30597073 | 0.79 | ALDH1A1 (0.68) | POLBRAB9ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL1706850 | 0.78 | ALDH1A1 (0.52) | POLBRAB9ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL1137355 | 0.75 | PTGS2 (0.49) | POLBRAB9ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL10752474 | 0.73 | ALDH1A1 (0.42) | POLBRAB9ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL27168526 | 0.71 | HSP90AA1 (0.47) | SMN1; SMN2ALDH1A1KMT2AKDM4EMEN1 | |
| SCHEMBL30596982 | 0.70 | KMT2A (0.47) | POLBRAB9ASMN1; SMN2ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001044185-A1 | CARBON MONOXIDE-BASED SYNTHESIS OF SPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 2001-06-21 | — | — | WO | disclosed |