Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7996943 | 0.81 | SMN1; SMN2 (0.60) | SMN1; SMN2NPSR1HSD17B10MAPTCYP1A2 | |
| SCHEMBL13834970 | 0.80 | NPSR1 (0.63) | SMN1; SMN2NPSR1HSD17B10MAPTCYP1A2 | |
| SCHEMBL21870336 | 0.80 | POLB (0.68) | SMN1; SMN2NPSR1HSD17B10MAPTCYP1A2 | |
| SCHEMBL16444873 | 0.77 | HDAC1 (0.69) | SMN1; SMN2NPSR1HSD17B10MAPTCYP1A2 | |
| SCHEMBL29513264 | 0.77 | HDAC1 (0.69) | SMN1; SMN2NPSR1HSD17B10MAPTCYP1A2 | |
| SCHEMBL17744840 | 0.77 | SMN1; SMN2 (0.71) | SMN1; SMN2NPSR1HSD17B10MAPTCYP1A2 | |
| SCHEMBL18360433 | 0.76 | HDAC1 (0.68) | SMN1; SMN2NPSR1HSD17B10MAPTCYP1A2 | |
| SCHEMBL9789598 | 0.76 | ALDH1A1 (0.68) | SMN1; SMN2NPSR1HSD17B10MAPTCYP1A2 | |
| SCHEMBL17744894 | 0.76 | MAPT (0.65) | SMN1; SMN2NPSR1HSD17B10MAPTCYP1A2 | |
| SCHEMBL18147630 | 0.75 | MAPT (0.63) | SMN1; SMN2NPSR1HSD17B10MAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140357611-A1 | COMPOUNDS AND METHODS OF TREATING OCULAR DISORDERS | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR NIH | 2014-12-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140357611-A1 | COMPOUNDS AND METHODS OF TREATING OCULAR DISORDERS | ALDH1A2, TYR, HRH2 | SMN1; SMN2 1417/4885NPSR1 254/4885HSD17B10 634/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.