Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | HPGD | P15428 | 5/20 | 0.54 |
| ▸ | GAA | P10253 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | CASP1 | P29466 | 1/20 | 0.54 |
| ▸ | CASP7 | P55210 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.53 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | MGLL | Q99685 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.44 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6299259 | 0.89 | KDM4E (0.58) | KDM4EALDH1A1MAPTHPGDGAA | |
| SCHEMBL12982214 | 0.87 | CYP1A2 (0.51) | ALDH1A1MAPTHPGDGAANPC1 | |
| SCHEMBL12693538 | 0.86 | KDM4E (0.66) | KDM4EALDH1A1MAPTHPGDGAA | |
| SCHEMBL26239641 | 0.85 | MGLL (0.50) | KDM4EALDH1A1MAPTHPGDCASP1 | |
| SCHEMBL3649186 | 0.84 | ERAP2 (0.54) | KDM4EALDH1A1MAPTHPGDGAA | |
| SCHEMBL8217393 | 0.83 | RARB (0.51) | KDM4EALDH1A1MAPTHPGDGAA | |
| SCHEMBL20178618 | 0.82 | ALDH1A1 (0.47) | KDM4EALDH1A1MAPTHPGDCASP1 | |
| SCHEMBL35610 | 0.82 | MGLL (0.48) | KDM4EALDH1A1MAPTHPGDATM | |
| SCHEMBL10291100 | 0.82 | MGLL (0.57) | KDM4EALDH1A1MAPTMGLLMEN1 | |
| SCHEMBL9761038 | 0.82 | RARB (0.53) | KDM4EALDH1A1MAPTHPGDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0817629-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2000-03-08 | — | — | EP | disclosed |
| EP-0817629-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1998-01-14 | — | — | EP | disclosed |
| US-5631280-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1997-05-20 | — | — | US | disclosed |
| WO-1996030014-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1996-10-03 | — | — | WO | disclosed |