Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 3/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.41 |
| ▸ | PGR | P06401 | 4/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 8/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | PDE1A | P54750 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.36 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14748450 | 0.84 | PDE4B (0.44) | ARPDE4BCHRM1PDE4AADRA1A | |
| SCHEMBL14470676 | 0.82 | PDE4B (0.53) | PDE4BCHRM1PDE4AADRA1APDE1A | |
| SCHEMBL14748448 | 0.80 | PDE4B (0.41) | ARPDE4BCHRM1PDE4AADRA1A | |
| SCHEMBL8007552 | 0.80 | PDE4A (0.50) | ARPDE4BPDE4APDE4CPDE4D | |
| SCHEMBL8004927 | 0.79 | PDE4B (0.56) | ARPDE4BPDE4APDE4CPDE4D | |
| SCHEMBL14748444 | 0.77 | AR (0.39) | ARPDE4BPGRCHRM1PDE4A | |
| SCHEMBL19622296 | 0.77 | AR (0.48) | ARPDE4BPGRSLC22A12TRPV4 | |
| SCHEMBL19622201 | 0.77 | PDE4B (0.48) | ARPDE4BPDE4APDE4CPDE4D | |
| SCHEMBL5801556 | 0.75 | PDE4A (0.49) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL14748455 | 0.75 | BACE1 (0.39) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3246034-A1 | BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS | Anacor Pharmaceuticals, Inc. (US) | 2017-11-22 | — | — | EP | disclosed |
| EP-2564857-A1 | Boron-containing small molecules as anti-inflammatory agents | Anacor Pharmaceuticals, Inc. (US) | 2013-03-06 | — | — | EP | disclosed |
| WO-2009111676-A2 | BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS | ANACOR PHARMACEUTICALS, INC (US) | 2009-09-11 | — | — | WO | disclosed |