SCHEMBL799734

SCHEMBL799734

O=C(ON1C(=O)CCC1=O)c1ccc(-c2c3ccc(=O)cc-3oc3cc(O)ccc23)c(C(=O)O)c1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
USP2 O75604 3/20 0.62
L3MBTL1 Q9Y468 1/20 0.62
MEN1 O00255 2/20 0.53
POLB P06746 2/20 0.53
KMT2A Q03164 2/20 0.53
ALPL P05186 1/20 0.53
ALPI P09923 1/20 0.53
ALPG P10696 1/20 0.53
CA9 Q16790 14/20 0.53
ATM Q13315 1/20 0.51
PLEC Q15149 1/20 0.51
CA1 P00915 12/20 0.50
CA2 P00918 12/20 0.50
CA12 O43570 6/20 0.50
ESR1 P03372 1/20 0.48
DNASE1L3 Q13609 1/20 0.48
PRMT1 Q99873 1/20 0.48
CA14 Q9ULX7 2/20 0.46
ALB P02768 1/20 0.45
CA7 P43166 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30179280 1.00 USP2 (0.62) USP2L3MBTL1MEN1POLBKMT2A
SCHEMBL29399313 0.97 USP2 (0.58) USP2L3MBTL1MEN1POLBKMT2A
SCHEMBL29415506 0.94 USP2 (0.56) USP2L3MBTL1MEN1POLBKMT2A
SCHEMBL2054802 0.94 USP2 (0.56) USP2L3MBTL1MEN1POLBKMT2A
SCHEMBL3728723 0.93 USP2 (0.57) USP2L3MBTL1MEN1POLBKMT2A
SCHEMBL12238065 0.89 USP2 (0.47) USP2L3MBTL1MEN1POLBKMT2A
SCHEMBL31327372 0.88 USP2 (0.50) USP2L3MBTL1MEN1POLBKMT2A
SCHEMBL20912026 0.86 USP2 (0.57) USP2L3MBTL1MEN1POLBKMT2A
SCHEMBL29352834 0.86 USP2 (0.56) USP2L3MBTL1MEN1POLBKMT2A
SCHEMBL6693395 0.86 USP2 (0.56) USP2L3MBTL1MEN1POLBKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 121 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220082501-A1 FLUORESCENCE QUENCHING IMMUNOASSAY IDEXX LABORATORIES, INC. 2022-03-17 US disclosed
WO-2021211969-A2 FLUORESCENCE QUENCHING IMMUNOSSAY IDEXX LABORATORIES, INC. (US) 2021-10-21 WO disclosed
EP-3116525-B1 TCO CONJUGATES AND METHODS FOR DELIVERY OF THERAPEUTIC AGENTS UNIV CALIFORNIA (US) 2021-06-23 EP disclosed
US-20210060188-A1 TCO CONJUGATES AND METHODS FOR DELIVERY OF THERAPEUTIC AGENTS THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK 2021-03-04 US disclosed
WO-2020225077-A1 PYRIMIDO[4,5-B]INDOL DERIVATIVES AS PDHK1 INHIBITORS IDORSIA PHARMACEUTICALS LTD (CH) 2020-11-12 WO disclosed
US-10806807-B2 TCO conjugates and methods for delivery of therapeutic agents THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2020-10-20 US disclosed
US-10408843-B2 Compositions and methods for detecting S-nitrosylation and S-sulfinylation THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2019-09-10 US disclosed
US-10391175-B2 BET bromodomain inhibitors and therapeutic methods using the same THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2019-08-27 US disclosed
US-10342882-B2 TCO conjugates and methods for delivery of therapeutic agents THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2019-07-09 US disclosed
US-10337317-B2 Wax tracers INSTITUTT FOR ENERGITEKNIKK (NO) 2019-07-02 US disclosed
US-20070224607-A1 Methods for identifying compounds of interest using encoded libraries PRAECIS PHARMACEUTICALS INCORPORATED (US) 2007-09-27 US disclosed
US-20070224607-A1 Methods for identifying compounds of interest using encoded libraries PRAECIS PHARMACEUTICALS INCORPORATED (US) 2007-09-27 US disclosed
US-7247734-B2 3,4-diarylpyrazoles and their use in the therapy of cancer VERNALIS (CAMBRIDGE) LIMITED (GB) 2007-07-24 US disclosed
WO-2007053358-A2 METHODS FOR IDENTIFYING COMPOUNDS OF INTEREST USING ENCODED LIBRARIES PRAECIS PHARMACEUTICALS, INC. (US) 2007-05-10 WO disclosed
US-20070042401-A1 Methods for synthesis of encoded libraries PRAECIS PHARMACEUTICALS, INC. (US) 2007-02-22 US disclosed
US-20070042401-A1 Methods for synthesis of encoded libraries PRAECIS PHARMACEUTICALS, INC. (US) 2007-02-22 US disclosed
WO-2006095234-A2 INTEGRIN TARGETED SYNTHETIC LIGANDS FOR DIAGNOSTIC AND THERAPEUTIC APPLICATIONS BRACCO IMAGING S.P.A. (IT) 2006-09-14 WO disclosed
US-20050222230-A1 3,4-diarylpyrazoles and their use in the therapy of cancer VERNALIS (CAMBRIDGE) LIMITED (GB) 2005-10-06 US disclosed
EP-1456180-A1 3,4-DIARYLPYRAZOLES AND THEIR USE IN THE THERAPY OF CANCER Vernalis (Oxford) Ltd (GB) 2004-09-15 EP disclosed
WO-2003055860-A1 3,4-DIARYLPYRAZOLES AND THEIR USE IN THE THERAPY OF CANCER VERNALIS (CAMBRIDGE) LIMITED (GB) 2003-07-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10342882-B2 TCO conjugates and methods for delivery of therapeutic agents FCGR2A, PAICS, CD47 USP2 2957/4885L3MBTL1 796/4885MEN1 1382/4885
US-20210060188-A1 TCO CONJUGATES AND METHODS FOR DELIVERY OF THERAPEUTIC AGENTS FCGR2A, PAICS, CD47 USP2 2957/4885L3MBTL1 796/4885MEN1 1382/4885
US-20220082501-A1 FLUORESCENCE QUENCHING IMMUNOASSAY NQO2, FCGRT, MPO USP2 1703/4885L3MBTL1 2835/4885MEN1 3279/4885
US-10391175-B2 BET bromodomain inhibitors and therapeutic methods using the same BRD4, BRDT, BRD3 USP2 1670/4885L3MBTL1 1160/4885MEN1 3205/4885
US-10806807-B2 TCO conjugates and methods for delivery of therapeutic agents FCGR2A, PAICS, CD47 USP2 2957/4885L3MBTL1 796/4885MEN1 1382/4885
US-20050222230-A1 3,4-diarylpyrazoles and their use in the therapy of cancer HSP90AB1, HSP90AA1, HSP90AB2P USP2 2347/4885L3MBTL1 1731/4885MEN1 4797/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.