SCHEMBL2054802

SCHEMBL2054802

O=C(ON1C(=O)CCC1=O)c1ccc(C(=O)O)c(-c2c3ccc(=O)cc-3oc3cc(O)ccc23)c1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
USP2 O75604 3/20 0.56
L3MBTL1 Q9Y468 1/20 0.56
DNASE1L3 Q13609 1/20 0.53
PRMT1 Q99873 1/20 0.53
MEN1 O00255 2/20 0.52
POLB P06746 2/20 0.52
KMT2A Q03164 2/20 0.52
ALPL P05186 1/20 0.52
ALPI P09923 1/20 0.52
ALPG P10696 1/20 0.52
ATM Q13315 1/20 0.50
PLEC Q15149 1/20 0.50
CA9 Q16790 9/20 0.46
CA1 P00915 7/20 0.46
CA2 P00918 7/20 0.46
CA12 O43570 2/20 0.46
ALB P02768 1/20 0.46
ESR1 P03372 1/20 0.44
CA14 Q9ULX7 1/20 0.42
CDC25A P30304 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29415506 1.00 USP2 (0.56) USP2L3MBTL1DNASE1L3PRMT1MEN1
SCHEMBL29399313 0.97 USP2 (0.58) USP2L3MBTL1DNASE1L3PRMT1MEN1
SCHEMBL30179280 0.94 USP2 (0.62) USP2L3MBTL1DNASE1L3PRMT1MEN1
SCHEMBL799734 0.94 USP2 (0.62) USP2L3MBTL1DNASE1L3PRMT1MEN1
SCHEMBL31327372 0.94 USP2 (0.50) USP2L3MBTL1DNASE1L3PRMT1MEN1
SCHEMBL3728723 0.88 USP2 (0.57) USP2L3MBTL1DNASE1L3PRMT1MEN1
SCHEMBL15150533 0.87 USP2 (0.60) USP2L3MBTL1DNASE1L3PRMT1MEN1
SCHEMBL18594982 0.87 USP2 (0.51) USP2L3MBTL1DNASE1L3PRMT1MEN1
SCHEMBL20821271 0.86 USP2 (0.55) USP2L3MBTL1DNASE1L3PRMT1MEN1
6-Carboxyfluorescein SCHEMBL9906208 0.85 USP2 (0.69) USP2L3MBTL1DNASE1L3PRMT1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 74 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12570654-B2 Nanoluc suicide substrates PROMEGA CORPORATION (US) 2026-03-10 US disclosed
US-20230382908-A1 NANOLUC SUICIDE SUBSTRATES PROMEGA CORPORATION 2023-11-30 US disclosed
US-11655247-B2 Nanoluc suicide substrates PROMEGA CORPORATION (US) 2023-05-23 US disclosed
US-20190337939-A1 NANOLUC SUICIDE SUBSTRATES PROMEGA CORPORATION 2019-11-07 US disclosed
US-20190048344-A1 CHEMICAL MODIFICATIONS OF MONOMERS AND OLIGONUCLEOTIDES WITH CYCLOADDITION ALNYLAM PHARMACEUTICALS INC (US) 2019-02-14 US disclosed
US-20180362559-A1 BONE ACTIVE NITROGEN-CONTAINING BISPHOSPHONATES WITH A NEAR INFRARED FLUORESCENT LABEL UNIVERSITY OF SOUTHERN CALIFORNIA (US) 2018-12-20 US disclosed
EP-2806898-B1 INTEGRIN ANTAGONIST CONJUGATES FOR TARGETED DELIVERY TO CELLS EXPRESSING VLA-4 HOFFMANN LA ROCHE (CH) 2018-07-18 EP disclosed
US-9845493-B2 Tunable fluorescence using cleavable linkers AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2017-12-19 US disclosed
US-9845493-B2 Tunable fluorescence using cleavable linkers AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2017-12-19 US disclosed
EP-2806897-B1 INTEGRIN ANTAGONIST CONJUGATES FOR TARGETED DELIVERY TO CELLS EXPRESSING LFA-1 HOFFMANN LA ROCHE (CH) 2017-08-02 EP disclosed
US-20090163375-A1 Use of Photopolymerization for Amplification and Detection of a Molecular Recognition Event THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE 2009-06-25 US disclosed
US-20090123372-A1 DEVELOPMENT OF MOLECULAR IMAGING PROBES FOR CARBONIC ANHYDRASE-IX USING CLICK CHEMISTRY SIEMENS MEDICAL SOLUTIONS USA, INC. 2009-05-14 US disclosed
US-20090123372-A1 DEVELOPMENT OF MOLECULAR IMAGING PROBES FOR CARBONIC ANHYDRASE-IX USING CLICK CHEMISTRY SIEMENS MEDICAL SOLUTIONS USA, INC. 2009-05-14 US disclosed
US-20090123372-A1 DEVELOPMENT OF MOLECULAR IMAGING PROBES FOR CARBONIC ANHYDRASE-IX USING CLICK CHEMISTRY SIEMENS MEDICAL SOLUTIONS USA, INC. 2009-05-14 US disclosed
WO-2008124703-A2 DEVELOPMENT OF MOLECULAR IMAGING PROBES FOR CARBONIC ANHYDRASE-IX USING CLICK CHEMISTRY SIEMENS MEDICAL SOLUTIONS USA, INC. (US) 2008-10-16 WO disclosed
WO-2008124703-A2 DEVELOPMENT OF MOLECULAR IMAGING PROBES FOR CARBONIC ANHYDRASE-IX USING CLICK CHEMISTRY SIEMENS MEDICAL SOLUTIONS USA, INC. (US) 2008-10-16 WO disclosed
US-7354706-B2 Use of photopolymerization for amplification and detection of a molecular recognition event THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) 2008-04-08 US disclosed
US-7354706-B2 Use of photopolymerization for amplification and detection of a molecular recognition event THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) 2008-04-08 US disclosed
US-20070243568-A1 Specific Substrates for O6-Alkylguanine-Dna Alkyltransferase EPFL ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (CH) 2007-10-18 US disclosed
US-20070243568-A1 Specific Substrates for O6-Alkylguanine-Dna Alkyltransferase EPFL ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (CH) 2007-10-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230382908-A1 NANOLUC SUICIDE SUBSTRATES XIAP, NLN, BAD USP2 1068/4885L3MBTL1 34/4885DNASE1L3 740/4885
US-20190048344-A1 CHEMICAL MODIFICATIONS OF MONOMERS AND OLIGONUCLEOTIDES WITH CYCLOADDITION DNMT1, LCK, MCTS1 USP2 4435/4885L3MBTL1 301/4885DNASE1L3 2043/4885
US-11655247-B2 Nanoluc suicide substrates XIAP, NLN, BAD USP2 1068/4885L3MBTL1 34/4885DNASE1L3 740/4885
US-20180362559-A1 BONE ACTIVE NITROGEN-CONTAINING BISPHOSPHONATES WITH A NEAR INFRARED FLUORESCENT LABEL PTH1R, BMP2, CALCR USP2 4581/4885L3MBTL1 3272/4885DNASE1L3 1670/4885
US-20090123372-A1 DEVELOPMENT OF MOLECULAR IMAGING PROBES FOR CARBONIC ANHYDRASE-IX USING CLICK CHEMISTRY CA9, CA4, CA13 USP2 968/4885L3MBTL1 4705/4885DNASE1L3 2522/4885
US-12570654-B2 Nanoluc suicide substrates NR3C1, LUC7L2, L3MBTL1 USP2 2887/4885L3MBTL1 3/4885DNASE1L3 2676/4885
US-20070243568-A1 Specific Substrates for O6-Alkylguanine-Dna Alkyltransferase AGT, AGXT, AGTR1 USP2 1746/4885L3MBTL1 32/4885DNASE1L3 1399/4885
US-20190337939-A1 NANOLUC SUICIDE SUBSTRATES XIAP, NLN, BAD USP2 1068/4885L3MBTL1 34/4885DNASE1L3 740/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.