Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLD1 | Q13393 | 1/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.44 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | STAT6 | P42226 | 1/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.40 |
| ▸ | PYGL | P06737 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8004108 | 1.00 | PLD1 (0.47) | PLD1HRH4CYP51A1DRD2HRH3 | |
| SCHEMBL2228283 | 0.84 | CYP51A1 (0.48) | HRH4CYP51A1DRD2STAT6TAS1R3 | |
| SCHEMBL2229048 | 0.80 | CYP51A1 (0.43) | HRH4CYP51A1DRD2STAT6TAS1R3 | |
| SCHEMBL2229050 | 0.80 | CYP51A1 (0.43) | HRH4CYP51A1DRD2STAT6TAS1R3 | |
| SCHEMBL7999347 | 0.80 | STAT6 (0.46) | PLD1STAT6TAS1R3TAS1R1CHRNA7 | |
| SCHEMBL1550688 | 0.80 | DRD2 (0.47) | HRH4CYP51A1DRD2STAT6TAS1R3 | |
| SCHEMBL7941749 | 0.78 | DRD2 (0.46) | HRH4CYP51A1DRD2STAT6TAS1R3 | |
| SCHEMBL7944428 | 0.78 | DRD2 (0.51) | HRH4CYP51A1DRD2STAT6TAS1R3 | |
| SCHEMBL1931303 | 0.78 | DRD2 (0.47) | HRH4CYP51A1DRD2STAT6TAS1R3 | |
| SCHEMBL1931738 | 0.78 | DRD2 (0.47) | HRH4CYP51A1DRD2STAT6TAS1R3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009146182-A1 | TRPV4 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-03 | — | — | WO | disclosed |