Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | STAT6 | P42226 | 1/20 | 0.42 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.41 |
| ▸ | SCN4A | P35499 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 2/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.39 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.39 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.39 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.39 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2229050 | 1.00 | CYP51A1 (0.43) | CYP51A1HRH4DRD2CYP2C9STAT6 | |
| SCHEMBL2228283 | 0.90 | CYP51A1 (0.48) | CYP51A1HRH4DRD2STAT6AKR1C3 | |
| SCHEMBL2364895 | 0.84 | DRD2 (0.44) | CYP51A1HRH4DRD2STAT6SCN3A | |
| SCHEMBL2364894 | 0.84 | DRD2 (0.44) | CYP51A1HRH4DRD2STAT6SCN3A | |
| SCHEMBL2227969 | 0.83 | HRH4 (0.45) | CYP51A1HRH4DRD2STAT6 | |
| SCHEMBL1929666 | 0.83 | PARP1 (0.45) | CYP51A1DRD2STAT6SCN3ASCN4A | |
| SCHEMBL7943270 | 0.82 | STAT6 (0.48) | CYP51A1HRH4DRD2CYP2C9STAT6 | |
| SCHEMBL6876269 | 0.80 | GHSR (0.44) | CYP51A1HRH4DRD2STAT6AKR1C3 | |
| SCHEMBL8004108 | 0.80 | PLD1 (0.47) | CYP51A1HRH4DRD2STAT6AKR1C3 | |
| SCHEMBL7997371 | 0.80 | PLD1 (0.47) | CYP51A1HRH4DRD2STAT6AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011091410-A1 | TRPV4 ANTAGONISTS | GLAXOS SMITHKLINE LLC (US) | 2011-07-28 | — | — | WO | disclosed |