Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.48 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | STAT6 | P42226 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.41 |
| ▸ | PYGL | P06737 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CCKBR | P32239 | 2/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2229050 | 0.90 | CYP51A1 (0.43) | CYP51A1HRH4DRD2STAT6AKR1C3 | |
| SCHEMBL2229048 | 0.90 | CYP51A1 (0.43) | CYP51A1HRH4DRD2STAT6AKR1C3 | |
| SCHEMBL2227969 | 0.87 | HRH4 (0.45) | CYP51A1HRH4DRD2STAT6 | |
| SCHEMBL6876269 | 0.86 | GHSR (0.44) | CYP51A1HRH4DRD2STAT6AKR1C3 | |
| SCHEMBL7997371 | 0.84 | PLD1 (0.47) | CYP51A1HRH4DRD2STAT6AKR1C3 | |
| SCHEMBL8004108 | 0.84 | PLD1 (0.47) | CYP51A1HRH4DRD2STAT6AKR1C3 | |
| SCHEMBL6873804 | 0.84 | HRH4 (0.43) | CYP51A1HRH4DRD2STAT6AKR1C3 | |
| SCHEMBL14964347 | 0.83 | DRD2 (0.47) | CYP51A1DRD2STAT6PYGLNPC1 | |
| SCHEMBL8012381 | 0.82 | DRD3 (0.41) | CYP51A1HRH4DRD2STAT6AKR1C3 | |
| SCHEMBL8004162 | 0.81 | MEN1 (0.36) | CYP51A1HRH4DRD2STAT6PYGL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011091410-A1 | TRPV4 ANTAGONISTS | GLAXOS SMITHKLINE LLC (US) | 2011-07-28 | — | — | WO | disclosed |