Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.65 |
| ▸ | LTA4H | P09960 | 1/20 | 0.64 |
| ▸ | HRH1 | P35367 | 1/20 | 0.64 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.58 |
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.51 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18917604 | 0.90 | LTA4H (0.75) | SIGMAR1LTA4HHRH1HRH3L3MBTL3 | |
| SCHEMBL11955057 | 0.89 | SIGMAR1 (0.65) | SIGMAR1LTA4HHRH1HRH3L3MBTL3 | |
| SCHEMBL19043080 | 0.87 | HRH3 (0.77) | LTA4HHRH3 | |
| SCHEMBL15922479 | 0.85 | SPHK1 (0.69) | SIGMAR1HRH1HRH3L3MBTL3L3MBTL1 | |
| SCHEMBL14501468 | 0.85 | HRH1 (0.86) | SIGMAR1LTA4HHRH1HRH3L3MBTL3 | |
| SCHEMBL492409 | 0.84 | HRH3 (0.83) | LTA4HHRH3 | |
| SCHEMBL15921650 | 0.84 | SPHK1 (0.68) | SIGMAR1HRH1HRH3L3MBTL3L3MBTL1 | |
| SCHEMBL15921209 | 0.84 | SPHK1 (0.68) | SIGMAR1HRH1HRH3L3MBTL3L3MBTL1 | |
| SCHEMBL19227711 | 0.83 | HRH3 (0.81) | HRH3L3MBTL3L3MBTL1MBTD1 | |
| SCHEMBL13849647 | 0.83 | HRH1 (0.72) | SIGMAR1LTA4HHRH1HRH3L3MBTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009117150-A2 | METHOD OF TREATING LUPUS WITH CERAMIDE DERIVATIVES | GENZYME CORPORATION (US) | 2009-09-24 | — | — | WO | disclosed |
| WO-2008150486-A2 | 2-ACYLAMINOPROPOANOL-TYPE GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | GENZYME CORPORATION (US) | 2008-12-11 | — | — | WO | disclosed |