Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A1 | P04798 | 2/20 | 0.52 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.51 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | AMY1A | P0DUB6 | 6/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MGAM | O43451 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SI | P14410 | 1/20 | 0.42 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.42 |
| ▸ | GUSB | P08236 | 1/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7396876 | 0.83 | ALOX5 (0.62) | CYP1A1CYP1B1CYP1A2NOX1PARP1 | |
| SCHEMBL7997761 | 0.82 | CYP1A1 (0.54) | CYP1A1CYP1B1CYP1A2NOX1PARP1 | |
| SCHEMBL7395692 | 0.81 | AMY1A (0.62) | CYP1A1CYP1B1CYP1A2NOX1PARP1 | |
| SCHEMBL28947822 | 0.80 | MAOB (0.52) | CHEK1ALOX5POLBALDH1A1HPGD | |
| SCHEMBL15456540 | 0.80 | CYP1A1 (0.69) | CYP1A1CYP1B1CYP1A2NOX1PARP1 | |
| SCHEMBL7400587 | 0.79 | AMY1A (0.65) | CYP1A1CYP1B1CYP1A2NOX1PARP1 | |
| SCHEMBL31737379 | 0.79 | CYP1A1 (0.58) | CYP1A1CYP1B1CYP1A2NOX1PARP1 | |
| SCHEMBL12470812 | 0.79 | CYP1A1 (0.58) | CYP1A1CYP1B1CYP1A2NOX1PARP1 | |
| SCHEMBL15224066 | 0.79 | CYP1A1 (0.55) | CYP1A1CYP1B1CYP1A2NOX1PARP1 | |
| SCHEMBL12470543 | 0.78 | AMY1A (0.61) | CYP1A1CYP1B1CYP1A2NOX1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288100-B1 | SUCH AS PHENYL-(2-PROPYL-1H-BENZIMIDAZOL-5-YL)-METHANONE USEFUL AS INHIBITORS OF SMOOTH MUSCLE CELL PROLIFERATION | AMERICAN HOME PRODUCTS CORPORATION | 2001-09-11 | — | — | US | claimed |