Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | MC4R | P32245 | 1/20 | 0.48 |
| ▸ | MC5R | P33032 | 1/20 | 0.48 |
| ▸ | PLG | P00747 | 3/20 | 0.46 |
| ▸ | F10 | P00742 | 7/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 3/20 | 0.45 |
| ▸ | PLAU | P00749 | 2/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.45 |
| ▸ | KLK1 | P06870 | 1/20 | 0.45 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | PROC | P04070 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7996357 | 0.94 | NPC1 (0.54) | NPC1MC4RMC5RPLGF10 | |
| SCHEMBL7999912 | 0.86 | MC4R (0.54) | NPC1MC4RMC5RPLGF10 | |
| SCHEMBL7999994 | 0.86 | MC4R (0.54) | NPC1MC4RMC5RPLGF10 | |
| SCHEMBL7999904 | 0.81 | F10 (0.53) | NPC1MC4RMC5RPLGF10 | |
| SCHEMBL7986772 | 0.81 | F10 (0.57) | NPC1MC4RMC5RPLGF10 | |
| SCHEMBL7996139 | 0.81 | F10 (0.54) | PLGF10F2PROC | |
| SCHEMBL7996092 | 0.80 | F10 (0.58) | MC4RMC5RPLGF10F2 | |
| SCHEMBL8003193 | 0.80 | F10 (0.58) | MC4RMC5RPLGF10F2 | |
| SCHEMBL7987038 | 0.80 | F10 (0.54) | PLGF10F2PRSS1HRH3 | |
| SCHEMBL7986928 | 0.79 | F10 (0.51) | PLGF10F2PLAUPRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000008005-A2 | PIPERAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2000-02-17 | — | — | WO | disclosed |