Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 6/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | FBP1 | P09467 | 2/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7998331 | 0.90 | NFE2L2 (0.48) | PTGES2NFE2L2MAOAMAOBFBP1 | |
| SCHEMBL8001632 | 0.86 | MAPT (0.48) | NFE2L2MAOAMAOBFBP1PPARG | |
| SCHEMBL8002291 | 0.83 | NFE2L2 (0.60) | NFE2L2FBP1 | |
| SCHEMBL7990203 | 0.83 | NFE2L2 (0.47) | PTGES2NFE2L2MAOAMAOBFBP1 | |
| SCHEMBL8002639 | 0.81 | NFE2L2 (0.43) | PTGES2NFE2L2MAOAMAOBFBP1 | |
| SCHEMBL7998940 | 0.81 | NFE2L2 (0.64) | NFE2L2FBP1 | |
| SCHEMBL7990162 | 0.81 | ALDH1A1 (0.51) | NFE2L2MAOBFBP1LMNAMEN1 | |
| SCHEMBL14788778 | 0.80 | POLB (0.50) | PTGES2NFE2L2MAOAMAOBF2 | |
| SCHEMBL16577588 | 0.78 | POLB (0.53) | PTGES2NFE2L2MAOAMAOBF2 | |
| SCHEMBL16019064 | 0.77 | POLB (0.52) | PTGES2NFE2L2F2PPARGLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009120783-A1 | HIGH AFFINITY INHIBITORS OF HEPATITIS C VIRUS NS3/4A PROTEASE | THE JOHNS HOPKINS UNIVERSITY (US) | 2009-10-01 | — | — | WO | disclosed |