Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 10/20 | 0.73 |
| ▸ | OPRK1 | P41145 | 10/20 | 0.73 |
| ▸ | HTR1A | P08908 | 7/20 | 0.73 |
| ▸ | DRD2 | P14416 | 3/20 | 0.73 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.73 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.73 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.73 |
| ▸ | MEN1 | O00255 | 1/20 | 0.73 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.73 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.73 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.73 |
| ▸ | TSHR | P16473 | 1/20 | 0.73 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.73 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.73 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.73 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.73 |
| ▸ | LMNA | P02545 | 1/20 | 0.73 |
| ▸ | DRD4 | P21917 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8014002 | 1.00 | OPRM1 (0.73) | OPRM1OPRK1HTR1ADRD2ADRA2A | |
| Hydrochloric Acid SCHEMBL7999277 | 0.99 | OPRM1 (0.72) | OPRM1OPRK1HTR1ADRD2ADRA2A | |
| Spiroxatrine SCHEMBL1255303 | 0.84 | DRD2 (1.00) | OPRM1OPRK1HTR1ADRD2ADRA2A | |
| SCHEMBL9455016 | 0.83 | OPRM1 (0.75) | OPRM1OPRK1HTR1ADRD2ADRA2A | |
| SCHEMBL9677855 | 0.79 | OPRM1 (0.67) | OPRM1OPRK1HTR1ADRD2ADRA2A | |
| SCHEMBL11721978 | 0.78 | OPRM1 (0.64) | OPRM1OPRK1HTR1ADRD2ADRA2A | |
| SCHEMBL9455222 | 0.78 | OPRM1 (0.68) | OPRM1OPRK1HTR1ADRD2ADRA2A | |
| SCHEMBL8095160 | 0.77 | OPRM1 (1.00) | OPRM1OPRK1HTR1ADRD2ADRA2A | |
| SCHEMBL11730445 | 0.77 | OPRM1 (0.63) | OPRM1OPRK1HTR1ADRD2ADRA2A | |
| SCHEMBL11728223 | 0.77 | OPRM1 (0.63) | OPRM1OPRK1HTR1ADRD2ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6060482-A | SEROTONIN INHIBITORS | BAYER AKTIENGESELLSCHAFT (DE) | 2000-05-09 | — | — | US | claimed |
| JP-5222040-A | — | — | None | — | — | JP | disclosed |
| US-6060482-A | SEROTONIN INHIBITORS | BAYER AKTIENGESELLSCHAFT (DE) | 2000-05-09 | — | — | US | disclosed |
| EP-0539803-B1 | Triazospirodecanone-methyl-chromans for the treatment of central nervous system illnesses | BAYER AG (DE) | 1999-01-07 | — | — | EP | disclosed |
| JP-H05222040-A | TRIAZASPIRODECANONE-METHYLCHROMANS | BAYER AG | 1993-08-31 | — | — | JP | disclosed |
| EP-0539803-A1 | Triazospirodecanone-methyl-chromans for the treatment of central nervous system illnesses | BAYER AG (DE) | 1993-05-05 | — | — | EP | disclosed |