Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 15/20 | 0.49 |
| ▸ | MMP9 | P14780 | 14/20 | 0.49 |
| ▸ | MMP1 | P03956 | 6/20 | 0.45 |
| ▸ | MMP13 | P45452 | 4/20 | 0.44 |
| ▸ | MMP14 | P50281 | 3/20 | 0.44 |
| ▸ | MMP8 | P22894 | 2/20 | 0.44 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.43 |
| ▸ | MMP3 | P08254 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7998659 | 0.88 | MMP2 (0.57) | MMP2MMP9MMP1MMP13 | |
| SCHEMBL7998740 | 0.79 | MMP9 (0.68) | MMP2MMP9MMP1 | |
| SCHEMBL7998746 | 0.79 | MMP9 (0.68) | MMP2MMP9MMP1 | |
| SCHEMBL7539100 | 0.74 | MMP2 (0.50) | MMP2MMP9MMP1MMP13MMP14 | |
| SCHEMBL8002779 | 0.74 | MMP2 (0.51) | MMP2MMP9MMP1MMP13ADAM17 | |
| SCHEMBL7990368 | 0.73 | MMP9 (0.54) | MMP2MMP9MMP1MMP13MMP14 | |
| SCHEMBL8002344 | 0.72 | MMP2 (0.51) | MMP2MMP9MMP1MMP13MMP8 | |
| SCHEMBL21649299 | 0.71 | MMP2 (0.55) | MMP2MMP9MMP1MMP13MMP14 | |
| SCHEMBL7998783 | 0.71 | MMP9 (0.54) | MMP2MMP9MMP1MMP13MMP14 | |
| SCHEMBL7990015 | 0.70 | MMP2 (0.64) | MMP2MMP9MMP1MMP13MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6294573-B1 | FOR THERAPY RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, OSTEOPENIAS SUCH AS OSTEOPOROSIS, PERIODONTITIS, GINGIVITIS, CORNEAL, EPIDERMAL OR GASTRIC ULCERATION, AND TUMOR GROWTH AND METASTASIS OR INVASION | ABBOTT LABORATORIES | 2001-09-25 | — | — | US | claimed |
| US-6294573-B1 | FOR THERAPY RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, OSTEOPENIAS SUCH AS OSTEOPOROSIS, PERIODONTITIS, GINGIVITIS, CORNEAL, EPIDERMAL OR GASTRIC ULCERATION, AND TUMOR GROWTH AND METASTASIS OR INVASION | ABBOTT LABORATORIES | 2001-09-25 | — | — | US | disclosed |