Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 5/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.51 |
| ▸ | KIF11 | P52732 | 1/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.42 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.41 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP14 | P50281 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GCK | P35557 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2646108 | 0.83 | ALPL (0.46) | MRGPRX1SLC22A12CNR2ALDH1A1L3MBTL1 | |
| SCHEMBL7450024 | 0.79 | HTR2A (0.47) | SLC6A4SLC6A2SLC6A3PTGS2MAPT | |
| SCHEMBL5892840 | 0.76 | TTR (0.45) | PTGS2ALDH1A1MAPK1HTTL3MBTL1 | |
| SCHEMBL6925883 | 0.75 | PTGS2 (0.60) | SLC6A4SLC6A3KIF11PTGS2NR3C1 | |
| SCHEMBL13680420 | 0.75 | SLC6A4 (0.58) | SLC6A4SLC6A2SLC6A3P2RY1ALDH1A1 | |
| SCHEMBL5546503 | 0.74 | SLC6A4 (0.70) | SLC6A4SLC6A2SLC6A3MAPTHTT | |
| SCHEMBL12952672 | 0.72 | SLC6A4 (0.48) | SLC6A4SLC6A2SLC6A3KIF11NR3C1 | |
| SCHEMBL514383 | 0.72 | PTGS2 (0.65) | SLC6A4SLC6A3KIF11PTGS2MMP2 | |
| SCHEMBL5209305 | 0.72 | CA12 (0.48) | PTGS2NR3C1MAPTALDH1A1GCK | |
| SCHEMBL5547961 | 0.71 | SLC6A4 (0.54) | SLC6A4SLC6A2SLC6A3KIF11P2RY1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6294573-B1 | FOR THERAPY RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, OSTEOPENIAS SUCH AS OSTEOPOROSIS, PERIODONTITIS, GINGIVITIS, CORNEAL, EPIDERMAL OR GASTRIC ULCERATION, AND TUMOR GROWTH AND METASTASIS OR INVASION | ABBOTT LABORATORIES | 2001-09-25 | — | — | US | disclosed |