Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 13/20 | 0.42 |
| ▸ | CA1 | P00915 | 12/20 | 0.42 |
| ▸ | CA9 | Q16790 | 10/20 | 0.42 |
| ▸ | CA12 | O43570 | 4/20 | 0.42 |
| ▸ | CA6 | P23280 | 3/20 | 0.42 |
| ▸ | CA5A | P35218 | 3/20 | 0.42 |
| ▸ | CA4 | P22748 | 2/20 | 0.42 |
| ▸ | CA7 | P43166 | 2/20 | 0.42 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | PTGES2 | Q9H7Z7 | 3/20 | 0.37 |
| ▸ | LDHA | P00338 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19280573 | 0.79 | IDO1 (0.53) | CA2CA1CA9CA12CA6 | |
| SCHEMBL31726638 | 0.78 | CA2 (0.47) | CA2CA1CA9CA12CA6 | |
| SCHEMBL574790 | 0.78 | CA2 (0.47) | CA2CA1CA9CA12CA6 | |
| SCHEMBL1128972 | 0.75 | CA2 (0.51) | CA2CA1CA9CA12CA6 | |
| SCHEMBL8349565 | 0.74 | CA2 (0.54) | CA2CA1CA9CA12CA6 | |
| SCHEMBL11046847 | 0.74 | CA2 (0.41) | CA2CA1CA9CA12CA6 | |
| SCHEMBL27351284 | 0.73 | P2RX4 (0.42) | CA2CA1CA9CA12CA6 | |
| SCHEMBL6939683 | 0.73 | FDPS (0.38) | — | |
| SCHEMBL1517165 | 0.73 | IDO1 (0.55) | CA2CA9CA12 | |
| SCHEMBL731097 | 0.73 | TAAR1 (0.52) | CA2CA1CA9CA12CA6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288100-B1 | SUCH AS PHENYL-(2-PROPYL-1H-BENZIMIDAZOL-5-YL)-METHANONE USEFUL AS INHIBITORS OF SMOOTH MUSCLE CELL PROLIFERATION | AMERICAN HOME PRODUCTS CORPORATION | 2001-09-11 | — | — | US | disclosed |
| EP-0830343-A1 | BENZIMIDAZOLE DERIVATIVES AS INHIBITORS OF SMOOTH MUSCLE CELL PROLIFERATION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-03-25 | — | — | EP | disclosed |
| WO-1996039390-A1 | BENZIMIDAZOLE DERIVATIVES AS INHIBITORS OF SMOOTH MUSCLE CELL PROLIFERATION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-12-12 | — | — | WO | disclosed |