Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 11/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | HPD | P32754 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8308667 | 0.87 | PSEN1 (0.45) | PSEN1MAPTTDP1MAPK1L3MBTL1 | |
| SCHEMBL7843126 | 0.85 | PSEN1 (0.44) | PSEN1MAPTTDP1PTPN1MEN1 | |
| SCHEMBL11440561 | 0.85 | PSEN1 (0.44) | PSEN1MAPTTDP1PTPN1MEN1 | |
| SCHEMBL29670864 | 0.85 | PSEN1 (0.44) | PSEN1MAPTTDP1PTPN1MEN1 | |
| SCHEMBL11440558 | 0.85 | PSEN1 (0.44) | PSEN1MAPTTDP1PTPN1MEN1 | |
| SCHEMBL10535389 | 0.85 | PSEN1 (0.43) | PSEN1MAPTTDP1MAPK1L3MBTL1 | |
| SCHEMBL20503424 | 0.85 | PSEN1 (0.43) | PSEN1MAPTTDP1MAPK1L3MBTL1 | |
| SCHEMBL8308662 | 0.85 | PSEN1 (0.43) | PSEN1MAPTTDP1MAPK1L3MBTL1 | |
| SCHEMBL6597291 | 0.84 | PSEN1 (0.65) | PSEN1PTGS1PTGS2CYP1A2CYP3A4 | |
| SCHEMBL4592776 | 0.84 | PSEN1 (0.65) | PSEN1PTGS1PTGS2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000010994-A1 | PROCESS FOR THE PREPARATION OF 2-(ARYLOXYMETHYL)-2,5,7,8-TETRAMETHYLCHROMAN-6-OLS | SANKYO COMPANY, LIMITED (JP) | 2000-03-02 | — | — | WO | disclosed |
| US-5110955-A | Chiral rhodium or palladium-diphosphine catalyst | HOFFMANN-LA ROCHE INC. (US) | 1992-05-05 | — | — | US | disclosed |
| EP-0392389-A2 | Process for the preparation of vinyl compounds | F. HOFFMANN-LA ROCHE AG (CH) | 1990-10-17 | — | — | EP | disclosed |
| US-4824971-A | 2-allylchromans | HOFFMAN-LA ROCHE INC. (US) | 1989-04-25 | — | — | US | disclosed |
| EP-0235510-B1 | 3,4-DIHYDRO-2,5,7,8-TETRAMETHYL-2H-1-BENZOPYRAN DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1989-03-08 | — | — | EP | disclosed |
| US-4806661-A | Chromanemelonate esters | HOFFMANN-LA ROCHE INC. (US) | 1989-02-21 | — | — | US | disclosed |
| US-4752646-A | 2-halochromans | HOFFMANN-LA ROCHE INC. (US) | 1988-06-21 | — | — | US | disclosed |
| EP-0235510-A2 | 3,4-Dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran derivatives and processes for their preparation | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1987-09-09 | — | — | EP | disclosed |
| US-4598160-A | Intermediate phenolic compounds for the catalytic synthesis of chromans | HOFFMANN-LA ROCHE INC. (US) | 1986-07-01 | — | — | US | disclosed |
| US-4026907-A | INTERMEDIATES FOR ALPHA-TOCOPHEROL | HOFFMANN-LA ROCHE INC. (US) | 1977-05-31 | — | — | US | disclosed |
| US-4018799-A | INTERMEDIATES FOR TOCOPHEROL | HOFFMANN-LA ROCHE INC. (US) | 1977-04-19 | — | — | US | disclosed |
| US-4003919-A | INTERMEDIATES FOR ALPHA-TOCOPHEROL | HOFFMANN-LA ROCHE INC. (US) | 1977-01-18 | — | — | US | disclosed |
| US-3947473-A | (6-HYDROXY-CHROMAN-2-YL) CARBOXYLIC ACID DERIVATIVES | HOFFMAN-LA ROCHE INC. (US) | 1976-03-30 | — | — | US | disclosed |