Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SI | P14410 | 1/20 | 0.39 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | HRH2 | P25021 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL674463 | 0.87 | LMNA (0.49) | LMNATSHRPOLBALDH1A1MAPT | |
| SCHEMBL8957048 | 0.87 | LMNA (0.49) | LMNATSHRPOLBALDH1A1MAPT | |
| SCHEMBL29700358 | 0.87 | LMNA (0.49) | LMNATSHRPOLBALDH1A1MAPT | |
| SCHEMBL3398661 | 0.83 | LMNA (0.46) | LMNATSHRPOLBALDH1A1KDM4E | |
| SCHEMBL8735577 | 0.83 | ALDH1A1 (0.50) | LMNATSHRPOLBALDH1A1KDM4E | |
| SCHEMBL23152723 | 0.82 | PAOX (0.41) | LMNATSHRPOLBALDH1A1KDM4E | |
| SCHEMBL18164971 | 0.81 | LMNA (0.45) | LMNATSHRPOLBALDH1A1KDM4E | |
| SCHEMBL66203 | 0.81 | SMN1; SMN2 (0.56) | LMNATSHRALDH1A1KDM4EMAPT | |
| SCHEMBL12156674 | 0.81 | TSHR (0.45) | LMNATSHRPOLBALDH1A1KDM4E | |
| SCHEMBL10256974 | 0.81 | ALDH1A1 (0.53) | LMNATSHRPOLBALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6294573-B1 | FOR THERAPY RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, OSTEOPENIAS SUCH AS OSTEOPOROSIS, PERIODONTITIS, GINGIVITIS, CORNEAL, EPIDERMAL OR GASTRIC ULCERATION, AND TUMOR GROWTH AND METASTASIS OR INVASION | ABBOTT LABORATORIES | 2001-09-25 | — | — | US | disclosed |