Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 2/20 | 0.80 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.72 |
| ▸ | GRM8 | O00222 | 1/20 | 0.72 |
| ▸ | GRM6 | O15303 | 1/20 | 0.72 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.72 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.72 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.72 |
| ▸ | GRM5 | P41594 | 1/20 | 0.72 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.72 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.72 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.72 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.72 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.72 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.72 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.72 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.72 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.72 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.72 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.72 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL8000337 | 1.00 | GSR (0.80) | GSRCYP1A2GRM8GRM6GRIN2D | |
| D-Glutamate SCHEMBL27400214 | 1.00 | GSR (0.80) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Lysine SCHEMBL7258645 | 1.00 | GSR (0.80) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Lysine SCHEMBL890044 | 1.00 | GSR (0.80) | GSRCYP1A2GRM8GRM6GRIN2D | |
| D-Glutamate SCHEMBL1079951 | 1.00 | GSR (0.80) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Lysine SCHEMBL1079952 | 1.00 | GSR (0.80) | GSRCYP1A2GRM8GRM6GRIN2D | |
| D-Glutamate SCHEMBL2415481 | 1.00 | GSR (0.80) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Lysine SCHEMBL205003 | 1.00 | GSR (0.80) | GSRCYP1A2GRM8GRM6GRIN2D | |
| D-Glutamate SCHEMBL21796040 | 1.00 | GSR (0.80) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Lysine SCHEMBL6034319 | 0.98 | GSR (0.77) | GSRCYP1A2GRM8GRM6GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2953978-A1 | PHOSPHORYLCHOLINE CONJUGATES AND USES THEREOF | Tel HaShomer Medical Research Infrastructure and Services Ltd. (IL) | 2015-12-16 | — | — | EP | disclosed |
| WO-2014122646-A1 | PHOSPHORYLCHOLINE CONJUGATES AND USES THEREOF | TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (IL) | 2014-08-14 | — | — | WO | disclosed |
| EP-1007074-A4 | HYPOTHALAMUS-SPECIFIC POLYPEPTIDES | SCRIPPS RESEARCH INST (US) | 2000-10-25 | — | — | EP | disclosed |
| EP-1007074-A1 | HYPOTHALAMUS-SPECIFIC POLYPEPTIDES | The Scripps Research Institute (US) | 2000-06-14 | — | — | EP | disclosed |
| WO-1998005352-A1 | HYPOTHALAMUS-SPECIFIC POLYPEPTIDES | THE SCRIPPS RESEARCH INSTITUTE (US) | 1998-02-12 | — | — | WO | disclosed |