Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.54 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 9/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.44 |
| ▸ | ANTXR2 | P58335 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | ELANE | P08246 | 2/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NQO1 | P15559 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7616307 | 0.78 | MAPT (0.46) | MAPTMCL1ALDH1A1MEN1KMT2A | |
| SCHEMBL6174518 | 0.78 | VKORC1 (0.55) | MAPTMCL1ALDH1A1MEN1KMT2A | |
| SCHEMBL20286037 | 0.78 | CA1 (0.40) | MAPTMCL1ALDH1A1MEN1KMT2A | |
| SCHEMBL805313 | 0.74 | MAPT (0.50) | MAPTMCL1ALDH1A1MEN1KMT2A | |
| SCHEMBL6172211 | 0.72 | MAPT (0.47) | MAPTMCL1ALDH1A1MEN1KMT2A | |
| SCHEMBL6174415 | 0.72 | CYP2C9 (0.58) | MAPTMCL1ALDH1A1MEN1KMT2A | |
| SCHEMBL6173554 | 0.72 | MAPT (0.47) | MAPTMCL1ALDH1A1MEN1KMT2A | |
| SCHEMBL6174417 | 0.72 | CYP2C9 (0.58) | MAPTMCL1ALDH1A1MEN1KMT2A | |
| SCHEMBL11794883 | 0.72 | MEN1 (0.44) | MAPTMCL1ALDH1A1MEN1KMT2A | |
| SCHEMBL7607429 | 0.72 | FFAR1 (0.53) | MAPTALDH1A1MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170157111-A1 | HIF INHIBITORS AND USE THEREOF | THE GENERAL HOSPITAL CORPORATION (US) | 2017-06-08 | — | — | US | disclosed |
| US-20170157111-A1 | HIF INHIBITORS AND USE THEREOF | THE GENERAL HOSPITAL CORPORATION (US) | 2017-06-08 | — | — | US | disclosed |
| US-20150023868-A1 | HIF INHIBITORS AND USE THEREOF | THE GENERAL HOSPITAL CORPORATION (US) | 2015-01-22 | — | — | US | disclosed |
| US-20120070369-A1 | HIF INHIBITORS AND USE THEREOF | THE GENERAL HOSPITAL CORPORATION (US) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120070369-A1 | HIF INHIBITORS AND USE THEREOF | HIF1AN, HIF1A, EGLN3 | MAPT 4004/4885MCL1 262/4885ALDH1A1 595/4885 |
| US-20150023868-A1 | HIF INHIBITORS AND USE THEREOF | HIF1AN, HIF1A, EGLN3 | MAPT 4004/4885MCL1 262/4885ALDH1A1 595/4885 |
| US-20170157111-A1 | HIF INHIBITORS AND USE THEREOF | HIF1AN, HIF1A, EGLN3 | MAPT 4004/4885MCL1 262/4885ALDH1A1 595/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.