Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 10/20 | 0.65 |
| ▸ | CTSK | P43235 | 9/20 | 0.65 |
| ▸ | CTSB | P07858 | 4/20 | 0.65 |
| ▸ | CTSL | P07711 | 2/20 | 0.65 |
| ▸ | BCL2 | P10415 | 1/20 | 0.59 |
| ▸ | AKT1 | P31749 | 1/20 | 0.57 |
| ▸ | ACE | P12821 | 1/20 | 0.57 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
| ▸ | REN | P00797 | 2/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA7 | P43166 | 1/20 | 0.53 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30193288 | 0.87 | CTSS (0.64) | CTSSCTSKCTSBCTSLBCL2 | |
| SCHEMBL8611600 | 0.87 | BCL2 (0.76) | CTSSCTSKCTSBCTSLBCL2 | |
| SCHEMBL1164315 | 0.86 | CTSS (0.63) | CTSSCTSKCTSBCTSLBCL2 | |
| SCHEMBL11979695 | 0.86 | CTSS (0.63) | CTSSCTSKCTSBCTSLBCL2 | |
| SCHEMBL5556757 | 0.85 | CTSS (0.71) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL3004474 | 0.85 | CTSS (0.71) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL3004471 | 0.85 | CTSS (0.71) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL11568520 | 0.84 | CTSS (0.67) | CTSSCTSKCTSBCTSLBCL2 | |
| SCHEMBL6161119 | 0.84 | CTSS (0.70) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL19513108 | 0.84 | CTSS (0.70) | CTSSCTSKCTSBCTSLAKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0991412-A4 | AMINOACYL SULFAMIDES FOR THE TREATMENT OF HYPERPROLIFERATIVE DISORDERS | CUBIST PHARM INC (US) | 2000-06-21 | — | — | EP | disclosed |
| EP-0991412-A1 | AMINOACYL SULFAMIDES FOR THE TREATMENT OF HYPERPROLIFERATIVE DISORDERS | Cubist Pharmaceuticals, Inc. (US) | 2000-04-12 | — | — | EP | disclosed |
| WO-1998041215-A1 | AMINOACYL SULFAMIDES FOR THE TREATMENT OF HYPERPROLIFERATIVE DISORDERS | CUBIST PHARMACEUTICALS, INC. (US) | 1998-09-24 | — | — | WO | disclosed |