Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | TTR | P02766 | 1/20 | 0.44 |
| ▸ | FDPS | P14324 | 1/20 | 0.43 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.42 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.39 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.39 |
| ▸ | ABAT | P80404 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2046004 | 0.83 | ALDH1A1 (0.63) | ALDH1A1TSHRTTRFDPSAOX1 | |
| SCHEMBL8004939 | 0.77 | ALDH1A1 (0.42) | ALDH1A1TSHRTTRFDPSAOX1 | |
| SCHEMBL13179869 | 0.72 | TTR (0.54) | ALDH1A1TSHRTTRFDPSAOX1 | |
| SCHEMBL5883547 | 0.71 | ALDH1A1 (0.59) | ALDH1A1TSHRTTRFDPSAOX1 | |
| SCHEMBL8035362 | 0.71 | ALDH1A1 (0.63) | ALDH1A1TSHRTTRFDPSAOX1 | |
| SCHEMBL24196783 | 0.71 | TTR (0.63) | ALDH1A1TSHRTTRFDPSAOX1 | |
| SCHEMBL7074229 | 0.71 | TTR (0.55) | ALDH1A1TSHRTTRFDPSAOX1 | |
| SCHEMBL5882232 | 0.70 | ALDH1A3 (0.52) | ALDH1A1TSHRTTRFDPSAOX1 | |
| SCHEMBL475342 | 0.70 | ALDH1A1 (0.61) | ALDH1A1TSHRTTRFDPSAOX1 | |
| SCHEMBL3952495 | 0.68 | PTGS1 (0.57) | ALDH1A1TSHRTTRFDPSAOX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000008202-A9 | 3-METHYLIDENYL-2-INDOLINONE MODULATORS OF PROTEIN KINASE | SUGEN INC (US) | 2000-07-27 | — | — | WO | disclosed |
| WO-2000008202-A2 | 3-METHYLIDENYL-2-INDOLINONE MODULATORS OF PROTEIN KINASE | SUGEN, INC. (US) | 2000-02-17 | — | — | WO | disclosed |