Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 16/20 | 0.65 |
| ▸ | CA2 | P00918 | 16/20 | 0.65 |
| ▸ | CA7 | P43166 | 16/20 | 0.65 |
| ▸ | CA9 | Q16790 | 16/20 | 0.65 |
| ▸ | CA4 | P22748 | 2/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7984798 | 0.79 | CA1 (1.00) | CA1CA2CA7CA9CA4 | |
| SCHEMBL11814244 | 0.77 | CA1 (0.40) | CA1CA2CA7CA9EPHX2 | |
| SCHEMBL12326178 | 0.64 | ACHE (0.44) | CA9ALDH1A1CYP3A4 | |
| SCHEMBL3070529 | 0.63 | L3MBTL1 (0.48) | CA1CA2CA7CA9EPHX2 | |
| SCHEMBL11814298 | 0.63 | ALDH1A1 (0.36) | CA1CA2CA7CA9ALDH1A1 | |
| SCHEMBL24756167 | 0.62 | CA1 (0.61) | CA1CA2CA7CA9CA4 | |
| SCHEMBL16071623 | 0.62 | ACHE (0.52) | CA1CA2CA7CA9CA4 | |
| SCHEMBL11387445 | 0.62 | ABCB1 (0.40) | CA1CA2CA7CA9EPHX2 | |
| SCHEMBL14390487 | 0.62 | KDM4E (0.55) | ALDH1A1MAPK1RECQL | |
| SCHEMBL4395035 | 0.62 | CA1 (1.00) | CA1CA2CA7CA9CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001079209-A2 | DIAZAFLUORENONE IL-8 ANTAGONISTS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2001-10-25 | — | — | WO | claimed |
| WO-2001079209-A2 | DIAZAFLUORENONE IL-8 ANTAGONISTS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2001-10-25 | — | — | WO | disclosed |