Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 4/20 | 0.42 |
| ▸ | ICAM1 | P05362 | 4/20 | 0.40 |
| ▸ | SELE | P16581 | 4/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | VCAM1 | P19320 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.34 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
| ▸ | LGALS3 | P17931 | 2/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 3/20 | 0.33 |
| ▸ | DRD3 | P35462 | 3/20 | 0.33 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1961073 | 0.91 | FAAH (0.50) | FAAHICAM1SELEKCNH2CA12 | |
| SCHEMBL8004561 | 0.76 | FAAH (0.51) | FAAHICAM1SELEKCNH2PTGS2 | |
| SCHEMBL12552087 | 0.74 | FAAH (0.61) | FAAHKCNH2CA12CA1CA2 | |
| SCHEMBL1961329 | 0.74 | FAAH (0.49) | FAAHICAM1SELEKCNH2VCAM1 | |
| SCHEMBL1962427 | 0.72 | FAAH (0.47) | FAAHKCNH2MEN1KMT2APTGS2 | |
| SCHEMBL1961326 | 0.71 | ICAM1 (0.41) | FAAHICAM1SELEKCNH2VCAM1 | |
| SCHEMBL12551943 | 0.71 | FAAH (0.54) | FAAHICAM1SELEKCNH2MEN1 | |
| SCHEMBL1964025 | 0.71 | FAAH (0.51) | FAAHICAM1SELEKCNH2VCAM1 | |
| SCHEMBL8008300 | 0.70 | FAAH (0.39) | FAAHKCNH2MEN1KMT2A | |
| SCHEMBL1962386 | 0.70 | FAAH (0.48) | FAAHKCNH2MEN1KMT2APTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009151991-A1 | PYRAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH | MERCK & CO., INC. (US) | 2009-12-17 | — | — | WO | disclosed |