Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 4/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1535319 | 0.91 | FAAH (0.49) | FAAHKCNH2ALDH1A1KDM4EMEN1 | |
| SCHEMBL8002415 | 0.70 | FAAH (0.42) | FAAHKCNH2MEN1KMT2A | |
| SCHEMBL1959648 | 0.69 | FAAH (0.50) | FAAHKCNH2ALDH1A1KDM4ERXFP1 | |
| SCHEMBL1964385 | 0.68 | FAAH (0.49) | FAAHKCNH2ALDH1A1KDM4EGAA | |
| SCHEMBL1535359 | 0.68 | FAAH (0.62) | FAAHKCNH2ALDH1A1KDM4ERXFP1 | |
| SCHEMBL3062248 | 0.67 | CYP2A6 (0.53) | FAAHALDH1A1KDM4EMAPK1RXRA | |
| SCHEMBL7992726 | 0.66 | FAAH (0.74) | FAAHKCNH2ALDH1A1KDM4EGAA | |
| SCHEMBL7992508 | 0.66 | FAAH (0.71) | FAAHKCNH2MEN1KMT2ACCNE1 | |
| SCHEMBL8004561 | 0.66 | FAAH (0.51) | FAAHKCNH2ALDH1A1KDM4EGAA | |
| SCHEMBL15070809 | 0.65 | FAAH (0.60) | FAAHKCNH2ALDH1A1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009151991-A1 | PYRAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH | MERCK & CO., INC. (US) | 2009-12-17 | — | — | WO | disclosed |