SCHEMBL8002517

SCHEMBL8002517

Cc1cc(Cc2c(Cl)cc(N3N=CCNC3=O)cc2Cl)ccc1C(=O)c1ccc(Cl)cc1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
CNR2 P34972 1/20 0.33
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
SRD5A2 P31213 2/20 0.33
HPD P32754 1/20 0.33
MT-CO1 P00395 1/20 0.32
MT-CO2 P00403 1/20 0.32
MAPT P10636 3/20 0.32
RAB9A P51151 1/20 0.32
KDM4A O75164 1/20 0.32
KDM5A P29375 1/20 0.32
KDM5B Q9UGL1 1/20 0.32
ABCB11 O95342 1/20 0.31
PTGS2 P35354 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
PARP1 P09874 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
GPR52 Q9Y2T5 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7470125 0.90 VNN1 (0.34) SRD5A2MT-CO1MT-CO2KDM4AKDM5B
SCHEMBL8002698 0.87 KDM4A (0.32) MT-CO1MT-CO2KDM4AKDM5AKDM5B
SCHEMBL7998737 0.86 KLKB1 (0.36) MEN1KMT2ASRD5A2HPDMT-CO1
SCHEMBL8001979 0.86 SRD5A2 (0.40) TP53TDP1CNR2MEN1KMT2A
SCHEMBL7838791 0.84 ALDH1A1 (0.35) MEN1KMT2AKDM4AKDM5BKDM4E
SCHEMBL7917032 0.84 ENPP2 (0.34) TDP1MEN1KMT2AMAPTPTGS2
SCHEMBL8002706 0.83 LSS (0.34) MEN1KMT2AMAPTRAB9ANPSR1
SCHEMBL7839566 0.83 KMT2A (0.39) TP53TDP1MEN1KMT2AMT-CO1
SCHEMBL7999106 0.82 CCR9 (0.33) TP53TDP1MEN1KMT2AMT-CO1
SCHEMBL8002378 0.82 KMT2A (0.41) TP53TDP1MEN1KMT2AMT-CO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6294536-B1 CONTROL OF PROTOZOA AND REDUCTION IN THE INCIDENCE OF ASSOCIATED DISEASES AND DEATH AND CONSEQUENT IMPROVEMENT IN RETARDED GROWTH AND GENERAL CONDITION AND PREVENTING DECREASE GROWTH AND GENERAL CONDITION TAKEDA SCHERING-PLOUGH ANIMAL HEALTH K.K. (JP) 2001-09-25 US disclosed