Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.52 |
| ▸ | TOP2A | P11388 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | CDC7 | O00311 | 1/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | CHUK | O15111 | 1/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | PAK4 | O96013 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | PRKCG | P05129 | 1/20 | 0.44 |
| ▸ | INSR | P06213 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3263121 | 0.78 | MAPK1 (0.43) | KDM4ECDC7PLK4CHEK1CHUK | |
| SCHEMBL8004181 | 0.77 | HRH1 (0.59) | LSSHRH3TOP2AKDM4EGUCY1B2 | |
| SCHEMBL26588845 | 0.74 | HRH3 (0.53) | LSSHRH3TOP2AHTR7KDM4E | |
| Hydrochloric Acid SCHEMBL10813003 | 0.74 | TOP2A (0.59) | LSSHRH3TOP2A | |
| SCHEMBL30866877 | 0.73 | HRH3 (0.49) | LSSHRH3TOP2AHTR7KDM4E | |
| SCHEMBL30866919 | 0.73 | HRH3 (0.49) | LSSHRH3TOP2AHTR7KDM4E | |
| SCHEMBL21512508 | 0.73 | HRH3 (0.49) | LSSHRH3TOP2AHTR7KDM4E | |
| SCHEMBL21512510 | 0.73 | HRH3 (0.49) | LSSHRH3TOP2AHTR7KDM4E | |
| SCHEMBL8415073 | 0.73 | HTR7 (0.84) | LSSHTR7KDM4EMAPK1ADRB2 | |
| SCHEMBL1386673 | 0.73 | SQOR (0.49) | KDM4ECDC7CDK1CDK2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000027394-A1 | ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | UNIVERSITY COLLEGE LONDON (GB) | 2000-05-18 | — | — | WO | disclosed |