Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 4/20 | 0.56 |
| ▸ | PRKCA | P17252 | 1/20 | 0.51 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 1/20 | 0.51 |
| ▸ | CCR1 | P32246 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | SPR | P35270 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | F11 | P03951 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7930702 | 0.81 | ADRA1A (0.56) | ADRA1APRKCAPTPN2HTR7CCR1 | |
| SCHEMBL8004598 | 0.81 | ADRA1A (0.53) | ADRA1APRKCAPTPN2HTR7CCR1 | |
| SCHEMBL16549656 | 0.81 | ADRA1A (0.55) | ADRA1APRKCAPTPN2HTR7CCR1 | |
| SCHEMBL6887265 | 0.78 | ADRA1A (0.52) | ADRA1APRKCAPTPN2HTR7CCR1 | |
| SCHEMBL7662399 | 0.78 | ADRA1A (0.45) | ADRA1AADRA1DADRA1BOPRM1 | |
| SCHEMBL761722 | 0.77 | PRKCA (0.51) | ADRA1APRKCAPTPN2HTR7CCR1 | |
| SCHEMBL7668741 | 0.77 | ADRA1A (0.44) | ADRA1AADRA1DADRA1BOPRM1 | |
| Hydrochloric Acid SCHEMBL7664053 | 0.77 | ADRA1A (0.44) | ADRA1AADRA1DADRA1BOPRM1 | |
| SCHEMBL3323620 | 0.76 | OPRM1 (0.50) | ADRA1APRKCAPTPN2HTR7OPRM1 | |
| Hydrochloric Acid SCHEMBL7664114 | 0.76 | ADRA1A (0.44) | ADRA1AADRA1DADRA1BOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000025782-A1 | DIHYDROPYRIDINONES AND PYRROLINONES USEFUL AS ALPHA 1A ADRENOCEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2000-05-11 | — | — | WO | disclosed |