Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | CCR1 | P32246 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.54 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.54 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.53 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.53 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.53 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7997749 | 0.85 | RIPK1 (0.65) | SMN1; SMN2KDM4ETP53LMNAMAPT | |
| SCHEMBL7997747 | 0.85 | TP53 (0.68) | SMN1; SMN2KDM4ETP53LMNAMAPT | |
| SCHEMBL3403675 | 0.83 | MAPT (0.78) | SMN1; SMN2KDM4ETP53LMNAMAPT | |
| SCHEMBL13902178 | 0.83 | SMN1; SMN2 (0.71) | SMN1; SMN2KDM4EROCK1TP53LMNA | |
| SCHEMBL13902182 | 0.81 | SMN1; SMN2 (0.68) | SMN1; SMN2KDM4EROCK1TP53LMNA | |
| SCHEMBL13902186 | 0.80 | SMN1; SMN2 (0.69) | SMN1; SMN2KDM4EROCK1TP53LMNA | |
| SCHEMBL16404208 | 0.80 | CNR1 (0.64) | SMN1; SMN2KDM4EMAPTRAB9AMEN1 | |
| SCHEMBL4018661 | 0.80 | POLB (0.70) | SMN1; SMN2KDM4EROCK1LMNAMAPT | |
| SCHEMBL13902183 | 0.80 | JAK3 (0.71) | SMN1; SMN2KDM4EROCK1LMNAMAPT | |
| SCHEMBL13902185 | 0.79 | SMN1; SMN2 (0.69) | SMN1; SMN2KDM4EROCK1TP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009115486-A1 | TRIAZOLE AMIDE DERIVATIVES FOR USE IN THERAPY | GLAXO GROUP LIMITED (GB) | 2009-09-24 | — | — | WO | disclosed |