Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.68 |
| ▸ | MAPT | P10636 | 6/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.62 |
| ▸ | LMNA | P02545 | 4/20 | 0.62 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.62 |
| ▸ | HTT | P42858 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | FLT3 | P36888 | 1/20 | 0.56 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | CCNC | P24863 | 1/20 | 0.53 |
| ▸ | CDK8 | P49336 | 1/20 | 0.53 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3403675 | 0.88 | MAPT (0.78) | TP53MAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL7997749 | 0.88 | RIPK1 (0.65) | TP53MAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL26733055 | 0.87 | NR1I2 (0.74) | TP53MAPTALDH1A1SMN1; SMN2NR1I2 | |
| SCHEMBL8003176 | 0.85 | SMN1; SMN2 (0.74) | TP53MAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL3400890 | 0.81 | SMN1; SMN2 (0.65) | TP53MAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL26732894 | 0.79 | KDM4E (0.71) | TP53MAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL25776304 | 0.78 | RIPK1 (0.79) | — | |
| SCHEMBL3407265 | 0.78 | MAPT (0.65) | TP53MAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL30335868 | 0.78 | MET (0.53) | TP53MAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL18762155 | 0.77 | TP53 (0.71) | TP53MAPTALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009115486-A1 | TRIAZOLE AMIDE DERIVATIVES FOR USE IN THERAPY | GLAXO GROUP LIMITED (GB) | 2009-09-24 | — | — | WO | disclosed |