Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.66 |
| ▸ | NPC1 | O15118 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | GLA | P06280 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 1/20 | 0.64 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7993807 | 0.90 | TRPM8 (0.55) | TRPM8NPC1ALDH1A1GLAHTT | |
| SCHEMBL27847921 | 0.84 | TRPM8 (0.64) | TRPM8NPC1ALDH1A1GLAHTT | |
| SCHEMBL1927016 | 0.82 | ALDH1A1 (0.69) | TRPM8NPC1ALDH1A1GLAHTT | |
| SCHEMBL8721927 | 0.80 | TRPM8 (1.00) | TRPM8NPC1ALDH1A1GLAHTT | |
| SCHEMBL8721921 | 0.80 | TRPM8 (1.00) | TRPM8NPC1ALDH1A1GLAHTT | |
| SCHEMBL7705043 | 0.78 | TP53 (0.56) | TRPM8NPC1ALDH1A1GLAHTT | |
| SCHEMBL5452605 | 0.78 | NPC1 (1.00) | TRPM8NPC1ALDH1A1GLAHTT | |
| SCHEMBL1385749 | 0.77 | ALDH1A1 (0.62) | TRPM8NPC1ALDH1A1GLAHTT | |
| Carbamic Acid SCHEMBL6468271 | 0.77 | NPC1 (0.62) | TRPM8NPC1ALDH1A1GLAHTT | |
| SCHEMBL10921379 | 0.77 | ALDH1A1 (0.62) | TRPM8NPC1ALDH1A1GLAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944636-A4 | PHENYL GLYOXAMIDES AS sPLA2 INHIBITORS | LILLY CO ELI (US) | 2000-07-12 | — | — | EP | disclosed |
| EP-0944636-A1 | PHENYL GLYOXAMIDES AS sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1999-09-29 | — | — | EP | disclosed |
| WO-1998024794-A1 | PHENYL GLYOXAMIDES AS sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1998-06-11 | — | — | WO | disclosed |