Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | TYR | P14679 | 2/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | MYC | P01106 | 1/20 | 0.36 |
| ▸ | MAX | P61244 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1719333 | 0.85 | TYR (0.41) | PIM1TYR | |
| SCHEMBL10132207 | 0.79 | MEN1 (0.39) | HSD11B1MEN1KMT2ACYP2C9 | |
| SCHEMBL11793971 | 0.79 | TYR (0.40) | PIM1TYRHSD11B1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL5671167 | 0.78 | — | — | |
| SCHEMBL11800670 | 0.76 | ALOX5 (0.42) | PIM1TYRHSD11B1MEN1KMT2A | |
| SCHEMBL7991720 | 0.76 | HSD11B1 (0.44) | PIM1HSD11B1MEN1KMT2ACYP2C9 | |
| SCHEMBL8005872 | 0.76 | MAOB (0.39) | HSD11B1MEN1KMT2ACYP2C9SLC6A3 | |
| SCHEMBL612898 | 0.75 | MAOB (0.43) | PIM1HSD11B1POLBRAB9ASLC6A4 | |
| SCHEMBL29218720 | 0.75 | OPRL1 (0.39) | TYRRAB9A | |
| SCHEMBL614021 | 0.75 | MEN1 (0.63) | MEN1KMT2ACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009156100-A1 | SUBSTITUTED ISOQUINOLINES AND ISOQUINOLINONES AS RHO KINASE INHIBITORS | SANOFI-AVENTIS (FR) | 2009-12-30 | — | — | WO | disclosed |