Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 16/20 | 0.52 |
| ▸ | DRD2 | P14416 | 10/20 | 0.51 |
| ▸ | DRD3 | P35462 | 7/20 | 0.50 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7833509 | 0.84 | DRD2 (0.59) | DRD4DRD2DRD3ADRA1DADRA1A | |
| SCHEMBL21274017 | 0.83 | DRD4 (0.50) | DRD4DRD2DRD3ADRA1DADRA1A | |
| SCHEMBL6196064 | 0.82 | DRD4 (0.52) | DRD4DRD2DRD3ADRA1DADRA1A | |
| SCHEMBL6198971 | 0.82 | ADRA1D (0.55) | DRD4DRD2DRD3ADRA1DADRA1A | |
| SCHEMBL10819399 | 0.81 | DRD4 (0.54) | DRD4DRD2DRD3ADRA1DADRA1A | |
| Hydrochloric Acid SCHEMBL7660487 | 0.81 | DRD4 (0.51) | DRD4DRD2DRD3ADRA1DADRA1A | |
| Hydrochloric Acid SCHEMBL8181520 | 0.81 | DRD4 (0.51) | DRD4DRD2DRD3ADRA1DADRA1A | |
| SCHEMBL7212038 | 0.79 | DRD4 (0.59) | DRD4DRD2DRD3ADRA1DADRA1A | |
| SCHEMBL6198252 | 0.79 | ADRA1D (0.49) | DRD4DRD2DRD3ADRA1DADRA1A | |
| SCHEMBL6198244 | 0.79 | ADRA1A (0.60) | DRD4DRD2DRD3ADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000025782-A1 | DIHYDROPYRIDINONES AND PYRROLINONES USEFUL AS ALPHA 1A ADRENOCEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2000-05-11 | — | — | WO | disclosed |