Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 3/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | PDE4A | P27815 | 2/20 | 0.41 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | FPR2 | P25090 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8229686 | 0.98 | HSD17B10 (0.43) | PDE4BPDE4DHSD17B10MAPTKDM4E | |
| Ammonia Solution, Strong SCHEMBL8004534 | 0.87 | PDE4A (0.48) | PDE4BPDE4DMAPTKDM4EPDE4A | |
| SCHEMBL7767598 | 0.84 | HSD17B10 (0.43) | PDE4BPDE4DHSD17B10MAPTKDM4E | |
| SCHEMBL8004519 | 0.84 | HSD17B10 (0.43) | PDE4BPDE4DHSD17B10MAPTKDM4E | |
| SCHEMBL4970595 | 0.81 | CA2 (0.46) | PDE4BPDE4DHSD17B10PDE4AL3MBTL1 | |
| SCHEMBL17534098 | 0.75 | CHRNB4 (0.52) | PDE4BPDE4DHSD17B10MAPTKDM4E | |
| SCHEMBL6582968 | 0.74 | CASP1 (0.45) | PDE4BPDE4DHSD17B10PDE4ASMPD1 | |
| SCHEMBL19657226 | 0.73 | NR1H4 (0.41) | MAPTL3MBTL1GAAHTT | |
| SCHEMBL11963234 | 0.73 | ACHE (0.63) | PDE4BMAPTKDM4EHPGDL3MBTL1 | |
| SCHEMBL17131593 | 0.73 | CA12 (0.63) | PDE4BPDE4DHSD17B10MAPTPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6025376-A | INHIBITORS OF TUMOR NECROSIS FACTOR, TREATING MULTIPLE SCLEROSIS | SCHERING AKTIENGESELLSCHAFT (DE) | 2000-02-15 | — | — | US | disclosed |