Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.41 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.40 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | APOBEC3A | P31941 | 2/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7233178 | 0.85 | ALOX15 (0.46) | ALOX15HSD11B1CHRM3HTTKCNA3 | |
| SCHEMBL6349140 | 0.79 | BDKRB1 (0.48) | ALOX15HSD11B1CHRM3HTTKCNA3 | |
| SCHEMBL19509382 | 0.78 | HSD11B1 (0.51) | ALOX15HSD11B1CHRM3HTTKCNA3 | |
| SCHEMBL19500368 | 0.78 | HSD11B1 (0.51) | ALOX15HSD11B1CHRM3HTTKCNA3 | |
| SCHEMBL349195 | 0.77 | MEN1 (0.56) | HSD11B1CHRM3HTTKCNA3OPRM1 | |
| SCHEMBL16897590 | 0.77 | OPRM1 (0.50) | ALOX15OPRM1ADRA1AADRA1DHRH3 | |
| SCHEMBL16897486 | 0.77 | OPRM1 (0.50) | ALOX15OPRM1ADRA1AADRA1DHRH3 | |
| SCHEMBL16897487 | 0.77 | OPRM1 (0.50) | ALOX15OPRM1ADRA1AADRA1DHRH3 | |
| SCHEMBL8013929 | 0.76 | MEN1 (0.66) | HSD11B1OPRM1BDKRB1LMNAKDM1A | |
| SCHEMBL2481767 | 0.74 | AKR1C1 (0.58) | HSD11B1CHRM3HTTKCNA3OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1014973-A4 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2000-09-20 | — | — | EP | claimed |
| EP-1014973-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2000-07-05 | — | — | EP | claimed |
| WO-1998057632-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1998-12-23 | — | — | WO | claimed |
| EP-1014973-A4 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2000-09-20 | — | — | EP | disclosed |
| EP-1014973-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2000-07-05 | — | — | EP | disclosed |
| US-6057350-A | Alpha 1a adrenergic receptor antagonists | MERCK & CO., INC. (US) | 2000-05-02 | — | — | US | disclosed |
| WO-1998057632-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1998-12-23 | — | — | WO | disclosed |