SCHEMBL8005887

SCHEMBL8005887

COc1cc2c(N)cc(-c3nc(C(F)(F)F)cs3)nc2cc1Cl

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC2A1 P11166 1/20 0.40
IGF1R P08069 2/20 0.35
GAA P10253 1/20 0.35
NPC1 O15118 1/20 0.35
HSP90AA1 P07900 2/20 0.33
HSP90AB1 P08238 2/20 0.33
KDM4E B2RXH2 2/20 0.32
ALDH1A1 P00352 2/20 0.32
PDE3B Q13370 1/20 0.32
PDE3A Q14432 1/20 0.32
PGK1 P00558 1/20 0.32
GSK3B P49841 1/20 0.32
MAP4K2 Q12851 1/20 0.32
EGFR P00533 1/20 0.31
ERBB2 P04626 1/20 0.31
EPHA2 P29317 1/20 0.31
KDR P35968 1/20 0.31
EPHB4 P54760 1/20 0.31
MAPT P10636 1/20 0.31
THRB P10828 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8006158 0.88 IGF1R (0.35) IGF1RNPC1HSP90AA1HSP90AB1PDE3B
SCHEMBL15216079 0.82 SLC2A1 (0.40) SLC2A1GAANPC1KDM4EALDH1A1
SCHEMBL7993018 0.81 SLC2A1 (0.41) SLC2A1GAANPC1HSP90AA1HSP90AB1
SCHEMBL8003565 0.80 KDM4E (0.41) SLC2A1NPC1KDM4EALDH1A1KDR
SCHEMBL8003756 0.79 KDM4E (0.36) NPC1KDM4EALDH1A1MAPTSMN1; SMN2
SCHEMBL577664 0.78 IGF1R (0.33) IGF1RPGK1GSK3BMAP4K2MAPT
SCHEMBL8005879 0.76 KDM4E (0.42) GAANPC1KDM4EALDH1A1PDE3B
SCHEMBL15216086 0.76 PDE4B (0.35) NPC1KDM4EALDH1A1MAPTSMN1; SMN2
SCHEMBL7996051 0.76 KMT2A (0.37) NPC1KDM4EALDH1A1MAPTSMN1; SMN2
SCHEMBL7996056 0.75 SLC2A1 (0.35) SLC2A1NPC1KDM4EALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009099596-A2 MACROCYCLIC SERINE PROTEASE INHIBITORS IDENIX PHARAMACEUTICALS, INC. (US) 2009-08-13 WO disclosed