Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.72 |
| ▸ | CASP1 | P29466 | 2/20 | 0.72 |
| ▸ | MAPT | P10636 | 2/20 | 0.72 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.72 |
| ▸ | CASP7 | P55210 | 1/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.67 |
| ▸ | MEN1 | O00255 | 3/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | TNF | P01375 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.48 |
| ▸ | PIN4 | Q9Y237 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL523511 | 0.84 | PIN1 (0.68) | HSD17B10CASP1MAPTALOX15CASP7 | |
| SCHEMBL7424373 | 0.84 | KMT2A (0.63) | HSD17B10MAPTKMT2AMEN1TNF | |
| SCHEMBL3862952 | 0.84 | TNF (0.51) | HSD17B10CASP1MAPTALOX15CASP7 | |
| SCHEMBL918351 | 0.82 | HDAC3 (0.56) | HSD17B10CASP1MAPTALOX15CASP7 | |
| SCHEMBL25358575 | 0.81 | HSD17B10 (1.00) | HSD17B10CASP1MAPTALOX15CASP7 | |
| SCHEMBL9798967 | 0.80 | ALDH1A1 (0.58) | HSD17B10MAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL2651666 | 0.79 | HSD17B10 (0.66) | HSD17B10CASP1MAPTALOX15CASP7 | |
| SCHEMBL7589770 | 0.79 | HDAC8 (0.59) | HSD17B10MAPTKMT2AMEN1GAA | |
| SCHEMBL7549194 | 0.79 | HDAC8 (0.59) | HSD17B10MAPTKMT2AMEN1GAA | |
| SCHEMBL2618100 | 0.79 | HDAC8 (0.59) | HSD17B10MAPTKMT2AMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6043254-A | ANTIPROLIFERATIVE AGENT; ENZYME INHIBITOR | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-03-28 | — | — | US | disclosed |
| WO-1999051590-A1 | SUBSTITUTED INDOLINONES AS KINASE INHIBITORS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1999-10-14 | — | — | WO | disclosed |