Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.66 |
| ▸ | PGR | P06401 | 1/20 | 0.66 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.63 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | TGM2 | P21980 | 1/20 | 0.62 |
| ▸ | RNF4 | P78317 | 1/20 | 0.62 |
| ▸ | PNLIP | P16233 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | CRHBP | P24387 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.58 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.58 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11509670 | 0.94 | PTPN1 (0.59) | HPGDSMN1; SMN2PGRPTPN1PTPN11 | |
| SCHEMBL28881974 | 0.85 | HPGD (0.62) | HPGDSMN1; SMN2PGRALDH1A1TGM2 | |
| SCHEMBL30053559 | 0.84 | CA12 (0.73) | HPGDSMN1; SMN2PGRALDH1A1TGM2 | |
| SCHEMBL4653369 | 0.84 | HPGD (0.70) | HPGDSMN1; SMN2PGRALDH1A1TGM2 | |
| SCHEMBL4292376 | 0.84 | GPR35 (0.67) | HPGDSMN1; SMN2PTPN11ALDH1A1TGM2 | |
| SCHEMBL21295380 | 0.82 | CA12 (0.71) | HPGDSMN1; SMN2PGRALDH1A1TGM2 | |
| SCHEMBL203013 | 0.82 | HPGD (0.63) | HPGDSMN1; SMN2PGRALDH1A1TGM2 | |
| SCHEMBL616739 | 0.81 | PTPN11 (0.75) | SMN1; SMN2PTPN1PTPN11NPC1RAB9A | |
| SCHEMBL10495628 | 0.81 | PTPN11 (0.74) | PTPN1PTPN11 | |
| SCHEMBL171438 | 0.81 | HPGD (0.71) | HPGDSMN1; SMN2PGRALDH1A1TGM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944636-A4 | PHENYL GLYOXAMIDES AS sPLA2 INHIBITORS | LILLY CO ELI (US) | 2000-07-12 | — | — | EP | disclosed |
| EP-0944636-A1 | PHENYL GLYOXAMIDES AS sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1999-09-29 | — | — | EP | disclosed |
| WO-1998024794-A1 | PHENYL GLYOXAMIDES AS sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1998-06-11 | — | — | WO | disclosed |